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The Scientific World Journal
Volume 2013, Article ID 284358, 7 pages
Review Article

Three-Dimensional Gait Analysis Can Shed New Light on Walking in Patients with Haemophilia

1Haemostasis and Thrombosis Unit, Saint-Luc University Clinics, 1200 Brussels, Belgium
2Physical Medicine and Rehabilitation Unit, Saint-Luc University Clinics, 1200 Brussels, Belgium
3Institute of Neuroscience (IoNS), Catholic University of Louvain, 1200 Brussels, Belgium
4Department of Biomedical Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, 3001 Heverlee, Belgium

Received 15 February 2013; Accepted 20 April 2013

Academic Editors: X. Feng, D. Lisini, and F. Querol

Copyright © 2013 Sébastien Lobet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In patients with haemophilia (PWH) (from Greek “blood love”), the long-term consequences of repeated haemarthrosis include cartilage damage and irreversible arthropathy, resulting in severe impairments in locomotion. Quantifying the extent of joint damage is therefore important in order to prevent disease progression and compare the efficacy of treatment strategies. Musculoskeletal impairments in PWH may stem from structural and functional abnormalities, which have traditionally been evaluated radiologically or clinically. However, these examinations are performed in a supine position (i.e., non-weight-bearing condition). We therefore suggest three-dimensional gait analysis (3DGA) as an innovative approach designed to focus on the functional component of the joint during the act of walking. This is of the utmost importance, as pain induced by weight-bearing activities influences the functional performance of the arthropathic joints significantly. This review endeavors to improve our knowledge of the biomechanical consequences of multiple arthropathies on gait pattern in adult patients with haemophilia using 3DGA. In PWH with arthropathy, the more the joint function was altered, the more the metabolic energy was consumed. 3DGA analysis could highlight the effect of an orthopedic disorder in PWH during walking. Indeed, mechanical and metabolic impairments were correlated to the progressive loss of active mobility into the joints.