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The Scientific World Journal
Volume 2013, Article ID 286075, 6 pages
http://dx.doi.org/10.1155/2013/286075
Research Article

Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia-Ischemia Encephalopathy

1Zoology Division, Department of Zoology, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan
2Department of Statistics, Bahauddin Zakariya University, Multan 60800, Pakistan

Received 2 August 2013; Accepted 25 August 2013

Academic Editors: F. A. Simmen and A. Surguchov

Copyright © 2013 Shahid Iqbal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10. Methods. 66 Blood samples (2% creatine monohydrate supplemented ( ) and unsupplemented ( )) were analyzed for various hematological (blood glucose, packed cell volume, total WBC count, total RBC count) and serum biochemical parameters (cholesterol, AST, ALT, HDL, LDL, total protein, triglycerides). Results. ALT had higher concentrations in mice feeding on normal diet for 8 ( ) and 12 weeks ( ) following asphyxia and in 12 weeks treatment without asphyxia ( ) when compared with the creatine supplemented mice. LDL ( ) and cholesterol ( ) had higher concentrations in mice on normal diet for 12 weeks following hypoxia ischemia. Cholesterol ( ) in 12 and glucose ( ) in 15 week treatment group had significantly lower concentrations in creatine supplemented male albino mice when compared with untreated group following hxpoic-ischemic insult. Conclusion. We concluded that creatine supplementation following hypoxic ischemic insult helps in maintain the normal blood chemistry.