Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia-Ischemia Encephalopathy

Table 1

Comparison of various hematological and serum biochemical parameters between 2% creatine monohydrate treated and untreated (control) male albino mice for 8 weeks following hypoxia and ischemia: data is expressed as mean ± standard deviation.

Parameters	Creatine monohydrate treated group		Untreated control group		𝑃 value
	Mean ± SD	Range	Mean ± SD	Range
Hematological profile
WBC (×10^9/L)	6.006 ± 2.648	11.5–2.65	5.833 ± 3.099	11.3–2.5	0.901 ns
RBC (×10^12/L)	4.96 ± 2.62	1.39–10.11	5.28 ± 1.14	4.0–7.18	0.748 ns
PCV%	25.8 ± 11.1	11.3–38	27.53 ± 8.27	12.2–42.5	0.731 ns
Glucose (mg/dL)	161.1 ± 38.4	98–214	136.2 ± 19.1	101–156	0.142 ns
MCV (fp)	84.6 ± 85.4	29.6–258.2	53.0 ± 15.4	27.8–78.2	0.370 ns
Serum biochemical profile
Total protein (g/dL)	38.00 ± 9.17	28–46	53.00 ± 1.00	53-54	0.106 ns
Triglycerides (mg/dL)	234 ± 125	130–393	280 ± 140	201–410	0.646 ns
Cholesterol (mg/dL)	824 ± 196	489–984	579 ± 208	411–811	0.174 ns
HDL (mg/dL)	49.00 ± 3.00	46–52	49 ± 1.00	48–50	1.000 ns
LDL (mg/dL)	662 ± 237	411–883	482 ± 222	283–722	0.408 ns
ALAT (𝜇/L)	23.67 ± 9.07	14–32	248.67 ± 8.08	240–256	𝑃>0.001^∗∗∗
ASAT (u/L)	156.0 ± 16.4	138–170	142.0 ± 20.0	122–162	0.417 ns

𝑃<0.05 = non-significant (ns), ^∗∗∗𝑃>0.001 = highly significant.