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The Scientific World Journal
Volume 2013 (2013), Article ID 292687, 11 pages
http://dx.doi.org/10.1155/2013/292687
Research Article

The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis

1Department of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, Turkey
2Department of Histology and Embryology, School of Medicine, Dokuz Eylül University, İzmir, Turkey
3Department of Biochemistry and Clinical Biochemistry, School of Medicine, Dokuz Eylül University, İzmir, Turkey
4Department of Anaesthesiology and Reanimation, Şifa Hospital, 35240 İzmir, Turkey
5Department of Anaesthesiology and Reanimation, Samandağ State Hospital, 31800 Hatay, Turkey

Received 3 December 2012; Accepted 15 January 2013

Academic Editors: W. W. Butt, B. Laviolle, S. Parthasarathy, and C. Weissman

Copyright © 2013 Uğur Koca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis.