Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013, Article ID 306476, 3 pages
http://dx.doi.org/10.1155/2013/306476
Research Article

Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole

School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia 750004, China

Received 24 April 2013; Accepted 25 June 2013

Academic Editors: A. Sacchetti, A. K. Saikia, and A. Sirit

Copyright © 2013 Qing Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. J. Mehta, S. S. Rajput, M. R. Patel, K. R. Patel, N. M. Patel, and M. Mothilal, “Formulation, development and optimization of metronidazole compression coated tablets,” Der Pharmacia Lettre, vol. 3, no. 5, pp. 94–103, 2011. View at Google Scholar · View at Scopus
  2. N. T. Vu, V. Aloumanis, M. J. Ben et al., “Stability of metronidazole benzoate in SyrSpend SF one-step suspension system,” International Journal of Pharmaceutical Compounding, vol. 12, no. 6, pp. 558–564, 2008. View at Google Scholar · View at Scopus
  3. S. Dubey, V. Jain, and G. B. Precthi, “Evaluation of lipophilicity, antimicrobial activity and mutagenicity of some novel ester prodrugs of metronidazole,” Indian Journal of Chemistry B, vol. 48, no. 11, pp. 1571–1576, 2009. View at Google Scholar · View at Scopus
  4. M. Johansen and C. Larsen, “A comparison of the chemical stability and the enzymatic hydrolysis of a series of aliphatic and aromatic ester derivatives of metronidazole,” International Journal of Pharmaceutics, vol. 26, no. 3, pp. 227–241, 1985. View at Google Scholar · View at Scopus
  5. E. K. Woodman, J. G. K. Chaffey, P. A. Hopes, D. R. J. Hose, and J. P. Gilday, “N,N′-carbonyldiimidazole-mediated amide coupling: significant rate enhancement achieved by acid catalysis with imidazole•HCI,” Organic Process Research and Development, vol. 13, no. 1, pp. 106–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. EDQM, EUROPEAN PHARMACOPOEIA 7. 0, metronidazole benzoate, 01/2008:0934.
  7. T. A. Higuchi and K. A. Connors, “Phase-solubility techniques,” Advances in Analytical Chemistry and Instrumentation, vol. 4, pp. 117–122, 1965. View at Google Scholar
  8. S. Göktürk, E. Çalışkan, R. Y. Talman, and U. Var, “A study on solubilization of poorly soluble drugs by cyclodextrins and micelles: complexation and binding characteristics of sulfamethoxazole and trimethoprim,” The Scientific World Journal, vol. 2012, Article ID 718791, 12 pages, 2012. View at Publisher · View at Google Scholar
  9. T. Loftsson and D. Duchêne, “Cyclodextrins and their pharmaceutical applications,” International Journal of Pharmaceutics, vol. 329, no. 1-2, pp. 1–11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. Q.-X. Guo, H.-Y. Liu, X.-Q. Ruan, X.-Q. Zheng, Y.-Y. Shi, and Y.-C. Liu, “Experimental and theoretical studies on the inclusion complexation of β-cyclodextrin with phenothiazine derivatives,” Journal of Inclusion Phenomena, vol. 35, no. 3, pp. 487–496, 1999. View at Google Scholar · View at Scopus