Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013 (2013), Article ID 365892, 5 pages
http://dx.doi.org/10.1155/2013/365892
Research Article

Antihyperlipidemic Effects of Sesamum indicum L. in Rabbits Fed a High-Fat Diet

1Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
3Physiology Research Center, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
5Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Received 13 May 2013; Accepted 24 July 2013

Academic Editors: C. Carbucicchio and A. N. Makaryus

Copyright © 2013 Sedigheh Asgary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Lloyd-Jones, R. J. Adams, T. M. Brown et al., “Heart disease and stroke statistics—2010 update: a report from the American Heart Association,” Circulation, vol. 121, no. 7, pp. 948–954, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. J. Lusis, “Atherosclerosis,” Nature, vol. 407, no. 6801, pp. 233–241, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. S. C. Joshi, “Plant and plant products used as hypolipidaemic/antiatherosclerotic agents: an overview,” Proceeding of Zoological Society of India, vol. 4, pp. 27–32, 2005. View at Google Scholar
  4. T. D. Souza, S. A. Mengi, S. Hassarajani, and S. Chattopadhayay, “Efficacy study of the bioactive fraction (F-3) of Acorus calamus in hyperlipidemia,” Indian Journal of Pharmacology, vol. 39, no. 4, pp. 196–200, 2007. View at Google Scholar · View at Scopus
  5. Z. A. Mahmood, M. Sualeh, S. B. Z. Mahmood, and M. A. Karim, “Herbal treatment for cardiovascular disease the evidence based therapy,” Pakistan Journal of Pharmaceutical Sciences, vol. 23, no. 1, pp. 119–124, 2010. View at Google Scholar · View at Scopus
  6. P. M. Kris-Etherton, K. D. Hecker, A. Bonanome et al., “Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer,” American Journal of Medicine, vol. 113, no. 9, pp. 71S–88S, 2002. View at Google Scholar · View at Scopus
  7. M. Serafini, R. Bellocco, A. Wolk, and A. M. Ekström, “Total antioxidant potential of fruit and vegetables and risk of gastric cancer,” Gastroenterology, vol. 123, no. 4, pp. 985–991, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Blazovics, A. Lugasi, K. Hagymasi, K. Szentmihalyi, and A. Kery, “Natural antioxidants and tissue regenerations: curative effect and reaction mechanism,” in Recent Progress in Medicinal Plants, D. K. Majumdar, J. N. Govil, and V. K. Singh, Eds., vol. 8, p. 107, Studium Press, 2003. View at Google Scholar
  9. S. Ghosal, A. Bhattacharya, and S. K. Bhattacharya, “Antioxidant effects of Emblica officinalis and their biological consequences,” in Recent Progress in Medicinal Plants, D. K. Majumdar, J. N. Govil, and V. K. Singh, Eds., vol. 8, p. 149, Studium Press, 2003. View at Google Scholar
  10. Y. Wenli, Z. Yaping, and S. Bo, “The radical scavenging activities of radix puerariae isoflavonoids: a chemiluminescence study,” Food Chemistry, vol. 86, no. 4, pp. 525–529, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. L. D. Kapoor, Hand Book of Ayurvedic Medicinal Plants, CRC Press, New York, NY, USA, 2001.
  12. M. Namiki, “Nutraceutical functions of sesame: a review,” Critical Reviews in Food Science and Nutrition, vol. 47, no. 7, pp. 651–673, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Gauthaman and T. S. Mohamed Saleem, “Nutraceutical value of sesame oil,” Pharmacognosy Reviews, vol. 3, no. 6, pp. 264–269, 2009. View at Google Scholar · View at Scopus
  14. K. P. Suja, A. Jayalekshmy, and C. Arumughan, “In vitro studies on antioxidant activity of lignans isolated from sesame cake extract,” Journal of the Science of Food and Agriculture, vol. 85, no. 10, pp. 1779–1783, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. B. Roma, M. M. Tabekhia, and J. D. Williams, “Phytate and oxalate contents in sesame seed (Sesamum indicum L.),” Nutrition Reports International, vol. 20, no. 1, pp. 25–31, 1979. View at Google Scholar · View at Scopus
  16. M. H. Kang, M. Naito, N. Tsujihara, and T. Osawa, “Sesamolin inhibits lipid peroxidation in rat liver and kidney,” Journal of Nutrition, vol. 128, no. 6, pp. 1018–1022, 1998. View at Google Scholar · View at Scopus
  17. M. H. Kang, Y. Kawai, M. Naito, and T. Osawa, “Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits,” Journal of Nutrition, vol. 129, no. 10, pp. 1885–1890, 1999. View at Google Scholar · View at Scopus
  18. M. H. Kang, M. Naito, K. Sakai, K. Uchida, and T. Osawa, “Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro,” Life Sciences, vol. 66, no. 2, pp. 161–171, 1999. View at Google Scholar · View at Scopus
  19. M. Lemcke-Norojärvi, A. Kamal-Eldin, L. Å. Appelqvist, L. H. Dimberg, M. Öhrvall, and B. Vessby, “Corn and sesame oils increase serum γ-tocopherol concentrations in healthy Swedish women,” Journal of Nutrition, vol. 131, no. 4, pp. 1195–1201, 2001. View at Google Scholar · View at Scopus
  20. T. Ide, M. Kushiro, Y. Takahashi, K. Shinohara, N. Fukuda, and S. Sirato-Yasumoto, “Sesamin, a sesame lignan, as a potent serum lipid-lowering food component,” Japan Agricultural Research Quarterly, vol. 37, no. 3, pp. 151–158, 2003. View at Google Scholar · View at Scopus
  21. G. Zuliani, M. Galvani, E. Leitersdorf, S. Volpato, M. Cavalieri, and R. Fellin, “The role of polyunsaturated fatty acids (PUFA) in the treatment of dyslipidemias,” Current Pharmaceutical Design, vol. 15, no. 36, pp. 4087–4093, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Babio, R. Balanza, J. Basulto, M. Bulló, and J. Salas-Salvadó, “Dietary fibre: influence on body weight, glycemic control and plasma cholesterol profile,” Nutricion Hospitalaria, vol. 25, no. 3, pp. 327–340, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Bhaskaran, N. Santanam, M. Penumetcha, and S. Parthasarathy, “Inhibition of atherosclerosis in low-density lipoprotein receptor-negative mice by sesame oil,” Journal of Medicinal Food, vol. 9, no. 4, pp. 487–490, 2006. View at Google Scholar · View at Scopus
  24. D. Sankar, G. Sambandam, M. Ramakrishna Rao, and K. V. Pugalendi, “Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils,” Clinica Chimica Acta, vol. 355, no. 1-2, pp. 97–104, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Asgari, M. Setorki, M. Rafieian-kopaei et al., “Postprandial hypolipidemic and hypoglycemic effects of Allium hertifolium and Sesamum indicum on hypercholesterolemic rabbits,” African Journal of Pharmacy and Pharmacology, vol. 6, pp. 1131–1135, 2012. View at Google Scholar
  26. F. Hirata, K. Fujita, Y. Ishikura, K. Hosoda, T. Ishikawa, and H. Nakamura, “Hypocholesterolemic effect of sesame lignan in humans,” Atherosclerosis, vol. 122, no. 1, pp. 135–136, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Kouchakzadeh, “Effect of centrifugation on temperature of sesame paste,” Agricultural Engineering International, vol. 14, no. 3, pp. 179–182, 2012. View at Google Scholar
  28. D. S. Bashi, B. S. F. Bazzaz, A. Sahebkar, M. M. Karimkhani, and A. Ahmadi, “Investigation of optimal extraction, antioxidant, and antimicrobial activities of Achillea biebersteinii and A. wilhelmsii,” Pharmaceutical Biology, vol. 50, no. 9, pp. 1168–1176, 2012. View at Publisher · View at Google Scholar
  29. V. L. Singleton and J. R. Rossi, “Colorimetry of total phenolics with phosphomolybdic-phosphotungestic acid reagent,” American Journal of Enology and Viticulture, vol. 16, no. 3, pp. 144–158, 1965. View at Google Scholar
  30. N. P. Visavadiya and A. V. R. L. Narasimhacharya, “Sesame as a hypocholesteraemic and antioxidant dietary component,” Food and Chemical Toxicology, vol. 46, no. 6, pp. 1889–1895, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Biswas, P. Dhar, and S. Ghosh, “Antihyperlipidemic effect of sesame (Sesamum indicum L.) protein isolate in rats fed a normal and high cholesterol diet,” Journal of Food Science, vol. 75, no. 9, pp. H274–H279, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Sirato-Yasumoto, M. Katsuta, Y. Okuyama, Y. Takahashi, and T. Ide, “Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver,” Journal of Agricultural and Food Chemistry, vol. 49, no. 5, pp. 2647–2651, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Kumar, A. Kamboj, and S. S. Sisodia, “Hepatoprotective activity of Sesamum indicum Linn. Against CCl4-induced hepatic damage in rats,” International Journal of Pharmaceutical and Biological Archive, vol. 2, no. 2, pp. 710–715, 2011. View at Google Scholar
  34. T. S. Mohamed Saleem, C. Madhusudhana Chetty, and S. Kavimani, “Sesame oil enhances endogenous antioxidants in ischemic myocardium of rat,” Revista Brasileira de Farmacognosia, vol. 22, no. 3, pp. 669–675, 2012. View at Publisher · View at Google Scholar
  35. E. Ernst and K. L. Resch, “Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature,” Annals of Internal Medicine, vol. 118, no. 12, pp. 956–963, 1993. View at Google Scholar · View at Scopus
  36. J. L. Peñalvo, A. Hopia, and H. Adlercreutz, “Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice,” European Journal of Nutrition, vol. 45, no. 8, pp. 439–444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Nakano, C. Itoh, F. Ishii et al., “Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats,” Biological and Pharmaceutical Bulletin, vol. 26, no. 12, pp. 1701–1705, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. M. Hu, H. Wang, W. C. Ye et al., “Flavones from flowers of Sesamum indicum,” China Journal of Chinese Materia Medica, vol. 32, no. 7, pp. 603–605, 2007. View at Google Scholar · View at Scopus
  39. N. Hirose, T. Inoue, K. Nishihara et al., “Inhibition of cholesterol absorption and synthesis in rats by sesamin,” Journal of Lipid Research, vol. 32, no. 4, pp. 629–638, 1991. View at Google Scholar · View at Scopus
  40. R. S. Parker, T. J. Sontag, and J. E. Swanson, “Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin,” Biochemical and Biophysical Research Communications, vol. 277, no. 3, pp. 531–534, 2000. View at Publisher · View at Google Scholar · View at Scopus