Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid
Table 2
Markers of lipid profile of the populations under study.
Parameters
(1) Effects of TGs levels (normal versus high) on normal and low HDL-c conditions/populations
(2) Effects of HDL-c levels (normal versus high) on normal and high TGs conditions
(3) Effects of variations of both HDL-c and TGs levels
Normal HDL-c ()
Low HDL-c ()
Normal TGs () Population A
High TGs () Population B
A versus B
Normal TGs () Population C
High TGs () Population D
C versus D
(Normal TGs) (A versus C)
(High TGs) (B versus D)
A versus D
B versus C
Total-c (mmol/L)
0.000
0.004
0.599
0.768
0.000
0.002
TGs (mmol/L)
0.000
0.000
0.049
0.006
0.000
0.000
HDL-c (mmol/L)
0.229
0.385
0.000
0.000
0.000
0.000
Large HDL (%)
0.000
0.541
0.000
0.646
0.000
0.295
Interm HDL (%)
0.474
0.667
0.017
0.311
0.071
0.064
Small HDL (%)
0.000
0.937
0.005
0.991
0.000
0.927
LDL-c (mmol/L)
0.049
0.517
0.176
0.831
0.029
0.937
Ox-LDL (U/L)
0.018
0.825
0.148
0.830
0.016
0.728
Ox-LDL/LDL-c
0.229
0.476
0.616
0.572
0.153
0.655
Non-HDL-c (mmol/L)
0.000
0.002
0.111
0.242
0.000
0.047
Total-c/HDL-c
0.000
0.002
0.000
0.000
0.000
0.194
LDL-c/HDL-c
0.037
0.539
0.000
0.001
0.000
0.032
TGs/HDL-c (mmol/L)
0.000
0.000
0.000
0.000
0.000
0.000
PON1 activity
0.593
0.778
0.776
0.918
0.902
0.810
Results are presented as media ± SEM. Independent samples -test and Mann-Whitney test for normalized and nonnormalized samples, respectively. HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; Ox-LDL: oxidized low-density lipoprotein; TGs: triglycerides; Total-c: total cholesterol.