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The Scientific World Journal
Volume 2013, Article ID 464698, 9 pages
Clinical Study

An Evil Backstage Manipulator: Psychological Factors Correlated with Health-Related Quality of Life in Chinese Patients with Crohn’s Disease

1Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
2Center for the Study of Inflammatory Bowel Disease, GI Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
3Department of Surgery, Jinling Hospital, Nursing College, Nanjing University of Chinese Medicine, Nanjing 210002, China
4Department of Surgery, Limb Preservation and Wound Care Research, VA New England Health Care Division, Providence, RI 02908, USA
5Department of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
6Department of General Surgery, Second Affiliated Hospital of Jilin University, General Surgery Center of Jilin University, Changchun 130000, China

Received 26 August 2013; Accepted 9 October 2013

Academic Editors: K. Aoyagi and P. Zezos

Copyright © 2013 Song Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Health-related quality of life (HRQoL) is recommended as one of essential parameters to evaluate treatment effect and clinical outcome in patients with Crohn’s disease (CD). Recent studies reported that psychological factors might play a role in HRQoL in Western and American CD patients. Sufficient evidences in Chinese CD patients are still unavailable. This study is dedicated to investigate the correlation of various psychological factors with HRQoL in Chinese CD patients. We prospectively collected 40 active and 40 quiescent CD patients in China and found that psychological factors, especially neuroticism and anxiety, significantly correlate with and affect HRQoL in both active and quiescent CD groups. This is the first report revealing correlation between psychological factors and HRQoL in Chinese CD patients. Therefore, we assume that our results can contribute to a better understanding of etiology and tailoring of management in Chinese patients with Crohn’s disease and are beneficial to our colleagues to compare the heterogeneous characteristics of Crohn’s disease in different ethnic groups.