Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine

Figure 4

Responses of intracellular Ca²⁺ to SCRT in cultured ICCs. ICCs were suspended in 2 mM Ca²⁺-containing normal solution. Increase in [Ca²⁺]_i was plotted against SCRT concentrations. (a) In normal conditions, [Ca²⁺]_i oscillations was induced. (b) SCRT 10 mg/mL had no response, but SCRT 50 mg/mL caused a sustained increase in [Ca²⁺]_i (c).

(a)

(b)

(c)