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The Scientific World Journal
Volume 2013, Article ID 538584, 6 pages
Research Article

Particle Formation by Supercritical Fluid Extraction and Expansion Process

1Engineering Research Center for Polymer Processing Equipment, Ministry of Education, School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100013, China

Received 7 August 2013; Accepted 4 September 2013

Academic Editors: E. Diaz and G. Morales

Copyright © 2013 Sujuan Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Supercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chinese herbal medicine. Supercritical fluid extraction is a green separation technology, which has been developed for decades and widely applied in traditional Chinese medicines or natural active components. In this paper, a SFEE patented instrument was firstly built up and controlled by LABVIEW work stations. Stearic acid was used to verify the SFEE process at optimized condition; via adjusting the preexpansion pressure and temperature one can get different sizes of particles. Furthermore, stearic acid was purified during the SFEE process with HPLC-ELSD detecting device; purity of stearic acid increased by 19%, and the device can purify stearic acid.