Research Article

Human SLC26A1 Gene Variants: A Pilot Study

Table 3

Predicted effect of missense gene variants on SAT1 protein structure stability, and allelic frequencies of these variants in the NCBI SNP database.

SLC26A1 variant aStability prediction bSVM scoreAllelic frequency this studyAllelic frequency cNCBI database cNCBI SNP accession

M132Tdecrease−0.90.038
R372Hdecrease−1.00.0380.0082rs73219719
Q556Rincrease0.20.3070.3484rs3796622

aPrediction of protein stability and bSupport Vector Machine modelling scores (values less than zero are significant) [10]. cNCBI database accessed on October 30 2012.