Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

Alinezhad, Heshmatollah; Mohseni Tavakkoli, Sahar

doi:https://doi.org/10.1155/2013/575636

The Scientific World Journal

On this page

Abstract Introduction Materials and Methods Results and Discussion Conclusion References Copyright Related Articles

Research Article | Open Access

Volume 2013 | Article ID 575636 | https://doi.org/10.1155/2013/575636

Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

Heshmatollah Alinezhad¹and Sahar Mohseni Tavakkoli¹

Academic Editor: L. Hadjiarapoglou, L. D'Accolti

Received25 Aug 2013

Accepted17 Sept 2013

Published30 Oct 2013

Abstract

A simple and convenient one-step method for synthesis of acridines and their derivatives from condensation of aromatic aldehydes, cyclic diketones, and aryl amines using Cu-doped ZnO nanocrystalline powder as a catalyst is reported. The present protocol provides several advantages such as good yields, short reaction time, easy workup, and simplicity in operation.

1. Introduction

In recent years, an increasing interest has been focused on the synthesis of 1,4-dihydropyridine compounds owing to their significant biological activities [1]. Substituted acridines have been used as antimalarials [2] for many years quite successfully and several of them have exhibited excellent results in chemotherapy of cancer [3–6]. These derivatives are frequently used in industry, especially for the production of dyes [7, 8]. Beside these properties, analogues of acridine have also been shown to have very long lasting efficiencies and have interesting electrochemical behavior [9, 10] of heterocyclic compounds and in the interaction with DNA [11].

Some methods are available in the literature for the synthesis of acridine derivatives containing 1,4-dihydropyridines, from dimedone, aldehyde, and different nitrogen sources like urea [12], methyl amine [13], and different anilines or ammonium acetate [14] via traditional heating in organic solvents in the presence of triethylbenzylammonium chloride (TEBAC) [15], p-dodecylbenzenesulfonic acid (DBSA) [16], Proline [17], Amberlyst-15 [18], ammonium chloride, Zn(OAc)₂·H₂O or L-proline [19], and/or under solvent-free conditions such as under microwave irradiation [20–22], sulfonic acid functionalized silica [23], ZnO nanoparticles [24], and nano-Fe₃O₄ [25] and using ionic liquids [26, 27] such as 1-methylimidazolium trifluoroacetate ([Hmim]TFA) [28] and Bronsted acidic imidazolium salts containing perfluoroalkyl tails [29]. Furthermore, some of these procedures suffer from other disadvantages, including the requirement for an expensive catalyst or the use of an excess of catalyst. To avoid these limitations and to improve the reaction conditions available for the synthesis of 1,8-dioxodecahydroacridines, the discovery of new methodologies using new heterogeneous and reusable catalysts is still in demand.

ZnO is considered to be one of the most important oxide materials owing to its unique features and wide range of technologically important applications. Moreover,it is cheap and environmentally friendly as compared to other metal oxides. Due to these properties, it has found potential applications in several fields such as gas sensors [30], solar cells [31], varistors [32], light emitting devices [33], photocatalyst [34], antibacterial activity [35], and cancer treatment [36]. ZnO lacks center of symmetry, which makes it beneficial for use in actuators and piezoelectric transducers. Properties of ZnO can be tuned according to the research interest, by doping with various metal atoms to suit specific needs and applications. The metal doping induces drastic changes in optical, electrical, and magnetic properties of ZnO by altering its electronic structure. Many authors have reported the changes induced by incorporation of transition metal ions into ZnO lattice [37–39]. albeit the large number of reports on transition metal-doped ZnO system, very less work is done on Cu-doped ZnO. Substitution of copper into the ZnO lattice has been shown to improve properties such as photocatalytic activity, gas sensitivity, and magnetic semiconductivity [40–42].

In continuation of our studies in developing efficient, simple, and environmentally benign methodologies for organic synthesis, we reveal herein the synthesis of N-substituted decahydroacridine-1,8-diones using Cu-doped ZnO nanocrystalline powder as a catalyst under solvent-free condition (Scheme 1).

2. Materials and Methods

2.1. General

All materials were purchased from Merck. The reactions were monitored by TLC using silica gel plates, and the products were purified by flash column chromatography on silica gel (Merck, 230–400 mesh) and were identified by comparison of their spectra (¹HNMR and ¹³CNMR) and physical data with those of the authentic samples. ¹H NMR and ¹³C NMR spectra were recorded with Brucker DRX500 AVANCE (400 MHz) spectrometers, using CDCl₃ as solvent. The morphology and elemental composition were characterized by a digital microscopy imaging scanning equipment VEGA 3 SB (TESCAN Co., s.r.o., Brno, Czech Republic) and energy dispersive X-ray spectrometer (EDS) attached to the SEM instrument with the operating voltage of 15 kV.

2.2. Synthesis of Cu-Doped ZnO Nanocrystalline Powder

Synthesis of Zn_1−xCu_xO (1% Cu-doped) nanopowder was carried out using the same technique followed by Cadar et al. [43] with some modifications after optimization of reaction conditions. The targets in the experiment were specifically designed using high purity of zinc nitrate hexahydrate (99.99%) and copper sulfate pentahydrate (99%) powders. The copper-doped ZnO catalyst was prepared by a two-step procedure: (1) preparation of precursor by coprecipitation method; (2) formation of Cu/ZnO nanopowder by thermal decomposition. The method has been considered to be fast, simple, and inexpensive, allowing for the production of fine, homogeneous crystalline powders without the risk of contamination.

The stoichiometric quantities of zinc and copper salts were dissolved in 100 mL deionized double distilled water (solution A). Separately, a solution was prepared by dissolving appropriate amounts of sodium hydroxide and sodium carbonate in deionized double distilled water (solution B). The solution A was heated to 85°C and the solution B was mixed dropwise into this solution with constant stirring. During the whole process, temperature was maintained at 85°C. This mixing was done for 1 h while refluxing through water condenser 85°C. Final solution was allowed to cool at room temperature and greenish precipitate that formed was washed three times with 20 mL deionized water in order to remove unnecessary impurities and dried overnight at 50°C under vacuum. Finally, the precursors were calcined at a temperature of 450°C for 90 min in the muffle furnace under air atmosphere to obtain the nanocrystalline Cu/ZnO powder.

Figure 1 shows scanning electron micrograph of nanocrystalline Zn_1−xCu_xO sample. In order to confirm the presence of Cu in the synthesized ZnO nanoparticles, the compositional analysis and purity of the as-synthesized nanocatalyst was obtained using EDS. Figure 2 shows the representative EDX spectra of nanocrystalline sample that the estimated amount of Cu dopant was nearly 1%. From the similarity of the Zn and Cu peak intensity line traces, it is clear that after the synthesis process, zinc and copper were homogenously distributed inside the nanoparticle.

2.3. General Experimental Procedure for N-Substituted Decahydroacridine-1,8-diones Formation Catalyzed by Cu-Doped ZnO Nanocrystalline Powder (Table 3, Entry 1)

A mixture of dimedone 1 (2 mmol), aromatic amine 2 (1 mmol), aromatic benzaldehyde 3 (1 mmol), and 10 mol% of Cu-doped ZnO nanocrystalline powder was heated in an oil bath at 90°C for 1.5 or 2 h. The reaction process was monitored by TLC (n-Hexane: EtOAc, 1 : 1). Upon completion of the transformation, the reaction mixture was cooled to room temperature and hot ethanol (15 mL) was added. This resulted in the precipitation of the catalyst, which was collected by filtration. The filtrate was distilled to dryness to give the crude product, which was recrystallized from a mixture of EtOH and H₂O to give compounds 4 in high to excellent yields (Scheme 1).

3. Results and Discussion

At first, to optimize the reaction condition, we studied the reaction of dimedone (2 mmol), aniline (1 mmol), and benzaldehyde (1 mmol) as model compounds in the presence of Cu-doped ZnO nanocrystalline powder (10 mol%) as a catalyst in solvent-free condition. We evaluated the effect of different solvents such as ethanol, H₂O, DMF, CH₂Cl₂, and solvent-free condition on the reaction rate under the same reaction conditions. Solvent-free condition afforded the products in higher yield and shorter reaction time (Table 1).

We next investigated the other amounts of Cu-doped ZnO nanocrystalline powder (5 and 15 mol%) for this reaction. The optimum yield of the N-substituted decahydroacridine-1,8-diones was obtained when 10 mol% of Cu-doped ZnO nanocrystalline powder was used (Table 2).

Therefore, in an optimized reaction condition dimedone (2 mmol), amine (1 mmol), and benzaldehyde (1 mmol) in an oil bath at 90°C were mixed with Cu-doped ZnO nanocrystalline powder (10 mol%) for 1.5 or 2 h (Table 3).

Subsequently, a variety of N-substituted decahydroacridine-1,8-diones were prepared from dimedone, various benzaldehyde derivatives, aniline derivatives, and benzylamine using the optimized reaction conditions and the results are summarized in Table 3.

As shown in Table 3 when the electron withdrawing substituents are present in benzaldehyde, the reaction rate increases, whereas the effect is reversed in the case of benzaldehyde with strong electron-donating substituents such as –OMe and –OH, of course with lower yields (entries 2, 13, 14, and 15). Orthosubstituted benzaldehyde also required relatively long reaction time towards para- and metasubstituted benzaldehydes (entries 7, 8, 9), because of its steric effect.

A plausible mechanism for the formation of the 1,8-dioxodecahydroacridine products using Cu-doped ZnO nanocrystalline powder as a catalyst has been depicted in Scheme 2. We propose that the nanoparticle induces the polarization of the carbonyl groups and facilitates the formation of the intermediates that subsequently react together to give the final products 4a–4r.

4. Conclusion

We have developed a new catalytic method for synthesis of 1,8-dioxodecahydroacridines using Cu-doped ZnO nanocrystalline powder as a catalyst in solvent-free condition by one-pot three-component condensation of aromatic aldehydes, dimedone, and aromatic and aliphatic amines. The simple experimental, workup procedure and catalyst preparation, high to excellent yields and using catalytic amount of Cu-doped ZnO nanocrystalline powder, are notable advantages of the method.

Acknowledgment

The financial support of this work from the Research Council of University of Mazandaran is gratefully acknowledged.

References

R. Shan, C. Velazquez, and E. E. Knaus, “Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl) pyridine-5-carboxylate racemates, enantiomers, and diastereomers,” Journal of Medicinal Chemistry, vol. 47, no. 1, pp. 254–261, 2004.
View at: Publisher Site | Google Scholar
S. Girault, P. Grellier, A. Berecibar et al., “Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2- methoxyacridines): influence of the linker,” Journal of Medicinal Chemistry, vol. 43, no. 14, pp. 2646–2654, 2000.
View at: Publisher Site | Google Scholar
W. M. Cholody, B. Horowska, J. Paradziej-Lukowicz, S. Martelli, and J. Konopa, “Structure-activity relationship for antineoplastic imidazoacridinones: synthesis and antileukemic activity in vivo,” Journal of Medicinal Chemistry, vol. 39, no. 5, pp. 1028–1032, 1996.
View at: Publisher Site | Google Scholar
T. K. Chen, R. Fico, and E. S. Canellakis, “Diacridines, bifunctional intercalators: chemistry and antitumor activity,” Journal of Medicinal Chemistry, vol. 21, no. 9, pp. 868–874, 1978.
View at: Google Scholar
W. A. Denny, G. J. Atwell, B. C. Baguley, and L. P. G. Wakelin, “Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity,” Journal of Medicinal Chemistry, vol. 28, no. 11, pp. 1568–1574, 1985.
View at: Google Scholar
G. W. Rewcastle, G. J. Atwell, D. Chambers, B. C. Baguley, and W. A. Denny, “Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide,” Journal of Medicinal Chemistry, vol. 29, no. 4, pp. 472–477, 1986.
View at: Google Scholar
B. D. Tilak and N. R. Ayyangar, “Chapter VIII. Acridine Dyes,” in Chemistry of Heterocyclic Compounds, vol. 9, pp. 579–613, 2nd edition, 1973.
View at: Google Scholar
A. Albert, The Acridines, Edward Arnold Publications, London, UK, 1966.
N. Srividya, P. Ramamurthy, P. Shanmugasundaram, and V. T. Ramakrishnan, “Synthesis, characterization, and electrochemistry of some acridine-1,8-dione dyes,” Journal of Organic Chemistry, vol. 61, no. 15, pp. 5083–5089, 1996.
View at: Google Scholar
F. Dollé, F. Hinnen, H. Valette et al., “Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging,” Bioorganic and Medicinal Chemistry, vol. 5, no. 4, pp. 749–764, 1997.
View at: Publisher Site | Google Scholar
Z. Hernandez-Gallegos, P. A. Lehmann, E. Hong, F. Posadas, and E. Hernandez-Gallegos, “Novel halogenated 1,4-dihydropyridines: synthesis, bioassay, microsomal oxidation and structure-activity relationships,” European Journal of Medicinal Chemistry, vol. 30, no. 5, pp. 355–364, 1995.
View at: Publisher Site | Google Scholar
A. A. Bakibaev, V. D. Fillimonov, and E. S. Nevgodova, “Ureas in the organic synthesis. Part 6: reactions of 1, 3-dicarbonyls with azomethines and urea in DMSO as a method for the synthesis of aryl-substituted acridine 1, 8-diones and 1, 4-dihydropyridines,” Russian Journal of Organic Chemistry, vol. 27, no. 7, pp. 1519–1524, 1991.
View at: Google Scholar
G.-P. Hua, S.-J. Tu, X.-T. Zhu et al., “One-pot synthesis of 10-methyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8- dione derivatives under microwave heating without catalyst,” Chinese Journal of Chemistry, vol. 23, no. 12, pp. 1646–1650, 2005.
View at: Publisher Site | Google Scholar
N. Martin, M. Quinteiro, C. Seoane et al., “Synthesis of conformational study of acridine derivatives related to 1,4-dihydropyridines,” Journal of Heterocyclic Chemistry, vol. 32, no. 1, pp. 235–238, 1995.
View at: Google Scholar
X.-S. Wang, D.-Q. Shi, Y.-F. Zhang, S.-H. Wang, and S.-J. Tu, “Synthesis of 9-arylpolyhydroacridine in water catalyzed by triethylbenzylammonium chloride (TEBA),” Chinese Journal of Organic Chemistry, vol. 24, no. 4, pp. 430–432, 2004.
View at: Google Scholar
T.-S. Jin, J.-S. Zhang, T.-T. Guo, A.-Q. Wang, and T.-S. Li, “One-pot clean synthesis of 1,8-dioxo-decahydroacridines catalyzed by p-dodecylbenezenesulfonic acid in aqueous media,” Synthesis, vol. 2004, no. 12, pp. 2001–2005, 2004.
View at: Publisher Site | Google Scholar
K. Venkatesan, S. S. Pujari, and K. V. Srinivasan, “Proline-catalyzed simple and efficient synthesis of 1,8-dioxo- decahydroacridines in aqueous ethanol medium,” Synthetic Communications, vol. 39, no. 2, pp. 228–241, 2009.
View at: Publisher Site | Google Scholar
B. Das, P. Thirupathi, I. Mahender, V. S. Reddy, and Y. K. Rao, “Amberlyst-15: an efficient reusable heterogeneous catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines,” Journal of Molecular Catalysis A, vol. 247, no. 1-2, pp. 233–239, 2006.
View at: Publisher Site | Google Scholar
S. Balalaie, F. Chadegani, F. Darviche, and H. R. Bijanzadeh, “One-pot synthesis of 1,8-dioxo-decahydroacridine derivatives in aqueous media,” Chinese Journal of Chemistry, vol. 27, no. 10, pp. 1953–1956, 2009.
View at: Publisher Site | Google Scholar
S.-J. Tu, C.-B. Miao, Y. Gao, Y.-J. Feng, and J.-C. Feng, “Microwave-prompted reaction of cinnamonitrile derivatives with 5,5-dimethyl-1,3-cyclohexanedione,” Chinese Journal of Chemistry, vol. 20, no. 7, pp. 703–706, 2002.
View at: Google Scholar
X.-S. Wang, D.-Q. Shi, S.-H. Wang, and S.-J. Tu, “Synthesis of 9-Aryl-10-(4-methylphenyl)polyhydroacridine under microwave irradiation,” Chinese Journal of Organic Chemistry, vol. 23, no. 11, pp. 1291–1293, 2003.
View at: Google Scholar
Z.-Q. Tang, Y. Chen, C.-N. Liu, K.-Y. Cai, and S.-J. Tu, “A green procedure for the synthesis of 1,8-dioxodecahydroacridine derivatives under microwave irradiation in aqueous media without catalyst,” Journal of Heterocyclic Chemistry, vol. 47, no. 2, pp. 363–367, 2010.
View at: Publisher Site | Google Scholar
G. M. Ziarani, A. Badiei, M. Hassanzadeh, and S. Mousavi, “Synthesis of 1,8-dioxo-decahydroacridine derivatives using sulfonic acid functionalized silica (SiO₂-Pr-SO₃H) under solvent free conditions,” Arabian Journal of Chemistry, 2011.
View at: Publisher Site | Google Scholar
J. Safaei-Ghomi, M. A. Ghasemzadeh, and S. Zahedi, “ZnO nanoparticles: a highly effective and readily recyclable catalyst for the one-pot synthesis of 1, 8-dioxo-decahydroacridine and 1, 8-dioxooctahydro-xanthene derivatives,” Journal of the Mexican Chemical Society, vol. 57, no. 1, pp. 1–7, 2013.
View at: Google Scholar
M. A. Ghasemzadeh, J. Safaei-Ghomi, and H. Molaei, “Fe₃O₄ nanoparticles: as an efficient, green and magnetically reusable catalyst for the one-pot synthesis of 1, 8-dioxo-decahydroacridine derivatives under solvent-free conditions,” Comptes Rendus Chimie, vol. 15, no. 11-12, pp. 969–974, 2012.
View at: Google Scholar
Y.-L. Li, M.-M. Zhang, X.-S. Wang et al., “One pot three component synthesis of 9-arylpolyhydroacridine derivatives in an ionic liquid medium,” Journal of Chemical Research, vol. 2005, no. 9, pp. 600–602, 2005.
View at: Google Scholar
G.-W. Wang, J.-J. Xia, C.-B. Miao, and X.-L. Wu, “Environmentally friendly and efficient synthesis of various 1,4-dihydropyridines in pure water,” Bulletin of the Chemical Society of Japan, vol. 79, no. 3, pp. 454–459, 2006.
View at: Publisher Site | Google Scholar
M. Dabiri, M. Baghbanzadeh, and E. Arzroomchilar, “1-Methylimidazolium triflouroacetate ([Hmim]TFA): an efficient reusable acidic ionic liquid for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines,” Catalysis Communications, vol. 9, no. 5, pp. 939–942, 2008.
View at: Publisher Site | Google Scholar
W. Shen, L.-M. Wang, H. Tian, J. Tang, and J.-J. Yu, “Brønsted acidic imidazolium salts containing perfluoroalkyl tails catalyzed one-pot synthesis of 1,8-dioxo-decahydroacridines in water,” Journal of Fluorine Chemistry, vol. 130, no. 6, pp. 522–527, 2009.
View at: Publisher Site | Google Scholar
F. Meng, J. Yin, Y.-Q. Duan, Z.-H. Yuan, and L.-J. Bie, “Co-precipitation synthesis and gas-sensing properties of ZnO hollow sphere with porous shell,” Sensors and Actuators B, vol. 156, no. 2, pp. 703–708, 2011.
View at: Publisher Site | Google Scholar
Z. Liu, C. Liu, J. Ya, and E. Lei, “Controlled synthesis of ZnO and TiO₂ nanotubes by chemical method and their application in dye-sensitized solar cells,” Renewable Energy, vol. 36, no. 4, pp. 1177–1181, 2011.
View at: Publisher Site | Google Scholar
K. Hembram, D. Sivaprahasam, and T. N. Rao, “Combustion synthesis of doped nanocrystalline ZnO powders for varistors applications,” Journal of the European Ceramic Society, vol. 31, no. 10, pp. 1905–1913, 2011.
View at: Publisher Site | Google Scholar
H. Kim, A. Piqué, J. S. Horwitz et al., “Effect of aluminum doping on zinc oxide thin films grown by pulsed laser deposition for organic light-emitting devices,” Thin Solid Films, vol. 377-378, pp. 798–802, 2000.
View at: Publisher Site | Google Scholar
K. C. Barick, S. Singh, M. Aslam, and D. Bahadur, “Porosity and photocatalytic studies of transition metal doped ZnO nanoclusters,” Microporous and Mesoporous Materials, vol. 134, no. 1–3, pp. 195–202, 2010.
View at: Publisher Site | Google Scholar
K. Rekha, M. Nirmala, M. G. Nair, and A. Anukaliani, “Structural, optical, photocatalytic and antibacterial activity of zinco xide and manganese doped zinc oxide nanoparticles,” Physica B, vol. 405, no. 15, pp. 3180–3185, 2010.
View at: Publisher Site | Google Scholar
H. Zhang, B. Chen, H. Jiang, C. Wang, H. Wang, and X. Wang, “A strategy for ZnO nanorod mediated multi-mode cancer treatment,” Biomaterials, vol. 32, no. 7, pp. 1906–1914, 2011.
View at: Publisher Site | Google Scholar
S. V. Bhat and F. L. Deepak, “Tuning the bandgap of ZnO by substitution with Mn²⁺, Co²⁺ and Ni²⁺,” Solid State Communications, vol. 135, no. 6, pp. 345–347, 2005.
View at: Publisher Site | Google Scholar
S. Deka and P. A. Joy, “Synthesis and magnetic properties of Mn doped ZnO nanowires,” Solid State Communications, vol. 142, no. 4, pp. 190–194, 2007.
View at: Publisher Site | Google Scholar
C. Jing, Y. Jiang, W. Bai, J. Chu, and A. Liu, “Synthesis of Mn-doped ZnO diluted magnetic semiconductors in the presence of ethyl acetoacetate under solvothermal conditions,” Journal of Magnetism and Magnetic Materials, vol. 322, no. 16, pp. 2395–2400, 2010.
View at: Publisher Site | Google Scholar
Y. S. Sonawane, K. G. Kanade, B. B. Kale, and R. C. Aiyer, “Electrical and gas sensing properties of self-aligned copper-doped zinc oxide nanoparticles,” Materials Research Bulletin, vol. 43, no. 10, pp. 2719–2726, 2008.
View at: Publisher Site | Google Scholar
D. B. Buchholz, R. P. H. Chang, J. H. Song, and J. B. Ketterson, “Room-temperature ferromagnetism in Cu-doped ZnO thin films,” Applied Physics Letters, vol. 87, no. 12, 2005.
View at: Publisher Site | Google Scholar
K. G. Kanade, B. B. Kale, J.-O. Baeg et al., “Self-assembled aligned Cu doped ZnO nanoparticles for photocatalytic hydrogen production under visible light irradiation,” Materials Chemistry and Physics, vol. 102, no. 1, pp. 98–104, 2007.
View at: Publisher Site | Google Scholar
O. Cadar, C. Roman, L. Gagea, I. Cernica, and A. Matei, “Synthesis, characterization and optimum reaction conditions for nanostructured zinc oxide,” Studia Universitatis Babes-Bolyai Chemia, vol. 4, no. 1, pp. 116–124, 2009.
View at: Google Scholar
M. Kidwai and D. Bhatnagar, “Ceric ammonium nitrate (CAN) catalyzed synthesis of N-substituted decahydroacridine-1,8-diones in PEG,” Tetrahedron Letters, vol. 51, no. 20, pp. 2700–2703, 2010.
View at: Publisher Site | Google Scholar
M. Hong and G. Xiao, “FSG-Hf(NPf2)4 catalyzed, environmentally benign synthesis of 1, 8-dioxo-decahydroaridines in water-ethanol,” Journal of Fluorine Chemistry, vol. 144, pp. 7–9, 2012.
View at: Google Scholar
J. J. Xia and K. H. Zhang, “Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water,” Molecules, vol. 17, no. 5, pp. 5339–5345, 2012.
View at: Google Scholar
H. Luo, Y. Kang, H. Nie, and L. Yang, “Fe³⁺-montmorillonite: an efficient solid catalyst for one-pot synthesis of decahydroacridine derivatives,” Journal of the Chinese Chemical Society, vol. 55, no. 6, pp. 1280–1285, 2008.
View at: Google Scholar
Y.-B. Shen and G.-W. Wang, “Solvent-free synthesis of xanthenediones and acridinediones,” Arkivoc, vol. 2008, no. 16, pp. 1–8, 2008.
View at: Google Scholar
W. Shen, L.-M. Wang, H. Tian, J. Tang, and J.-J. Yu, “Brønsted acidic imidazolium salts containing perfluoroalkyl tails catalyzed one-pot synthesis of 1,8-dioxo-decahydroacridines in water,” Journal of Fluorine Chemistry, vol. 130, no. 6, pp. 522–527, 2009.
View at: Publisher Site | Google Scholar
S. Tu, T. Li, Y. Zhang et al., “New reaction of Schiff base with dimedone: new method for the acridine derivatives under microwave irradiation,” Journal of Heterocyclic Chemistry, vol. 44, no. 1, pp. 83–88, 2007.
View at: Google Scholar
W. Shen, L.-M. Wang, H. Tian, J. Tang, and J.-J. Yu, “Brønsted acidic imidazolium salts containing perfluoroalkyl tails catalyzed one-pot synthesis of 1,8-dioxo-decahydroacridines in water,” Journal of Fluorine Chemistry, vol. 130, no. 6, pp. 522–527, 2009.
View at: Publisher Site | Google Scholar
A. Nakhi, P. T. V. A. Srinivas, M. S. Rahman et al., “Amberlite IR-120H catalyzed MCR: design, synthesis and crystal structure analysis of 1, 8-dioxodecahydroacridines as potential inhibitors of sirtuins,” Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 6, pp. 1828–1833, 2013.
View at: Google Scholar
Q. H. To, Y. R. Lee, and S. H. Kim, “Efficient one-pot synthesis of acridinediones by indium(III) triflate-catalyzed reactions of β-enaminones, aldehydes, and cyclic 1,3-dicarbonyls,” Bulletin of the Korean Chemical Society, vol. 33, no. 4, pp. 1170–1176, 2012.
View at: Google Scholar

Copyright

Copyright © 2013 Heshmatollah Alinezhad and Sahar Mohseni Tavakkoli. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation

Download other formats

Order printed copies

Views

2095

Downloads

1534

Citations