Molecular Dynamic Simulation to Explore the Molecular Basis of Btk-PH Domain Interaction with Ins(1,3,4,5)P4

Figure 4

Residue fluctuations obtained by average residual fluctuations between residues 1 and 70 for six simulations, wild type (WT), K19E, E41K, K12R, and K12R-R28C/H, over the 20 ns simulations are illustrated in solid lines. The residues of β1-β2 loop are highlighted.