Reestablishment of Ischemia-Reperfusion Liver Injury by N-Acetylcysteine Administration prior to a Preconditioning Iron Protocol
Figure 5
Effects of N-acetylcysteine (NAC) and/or iron (Fe) short-term administration on liver p65 nuclear factor-B (NF-B) DNA binding in rats subjected to ischemia-reperfusion (IR) (a), net changes in NF-B activation (b), and correlation between NF-B DNA binding and glutathione levels (c). Animals were treated as shown in Figure 1. Data are expressed as means ± SEM for 3 to 5 animals per group. Significance studies (; one-way ANOVA and the Newman-Keuls’ test) are indicated by the letters (a) or numbers (b) identifying each experimental group. In b, net changes in liver p65 NF-B DNA binding induced by IR correspond to the differences between groups (b-a) (controls), (d-c) (Fe), (f-e) (NAC), and (h-g) (NAC + Fe).
