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The Scientific World Journal
Volume 2013 (2013), Article ID 608683, 6 pages
Clinical Study

Effects of Metoprolol and Nebivolol on Exercise Blood Pressure in Patients with Mild Hypertension

1Department of Cardiology, School of Medicine, Eskişehir Osmangazi University, 26000 Eskişehir, Turkey
2Department of Anatomy, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey

Received 11 August 2013; Accepted 15 September 2013

Academic Editors: E. T. Martin and K. Okamatsu

Copyright © 2013 Huseyin Ugur Yazici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. We planned to compare the impact of two beta blockers, metoprolol and nebivolol, on arterial blood pressure during exercise in patients with mild hypertension. Methods. A total of 60 patients (13 males, 47 females; mean age: years) were enrolled in the present study. The patients were randomly selected to receive either nebivolol 5 mg/day ( ) or metoprolol 50 mg/day ( ) for 8 weeks. At the end of the 8th week, each of the patients received exercise stress test according to Bruce protocol and their blood pressures were remeasured after rest, exercise, and recovery. Results. Blood pressures were determined to be similar between metoprolol and nebivolol groups during rest, exercise, and recovery periods. Metoprolol and nebivolol achieved similar reductions in blood pressures during rest and exercise. However, five patients in nebivolol group and four patients in metoprolol group developed exaggerated BP response to exercise but the difference between metoprolol and nebivolol was not meaningful ( ). Conclusion. The results of the present study showed that metoprolol and nebivolol established comparable effects on the control of blood pressures during exercise in the patients with mild hypertensions.