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The Scientific World Journal
Volume 2013, Article ID 609151, 7 pages
http://dx.doi.org/10.1155/2013/609151
Research Article

Detection of MUC1-Expressing Ovarian Cancer by C595 Monoclonal Antibody-Conjugated SPIONs Using MR Imaging

1Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Medical Physics and Radiation Technology, School of Paramedical Sciences, Bushehr University of Medical Sciences, Bushehr, Iran

Received 5 August 2013; Accepted 1 September 2013

Academic Editors: A. Ciarmiello and B. Schaller

Copyright © 2013 Daryoush Shahbazi-Gahrouei and Mohammad Abdolahi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Ling, K. Wei, Y. Luo, X. Gao, and S. Zhong, “Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy,” Biomaterials, vol. 32, no. 29, pp. 7139–7150, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Markert, S. Lassmann, B. Gabriel et al., “Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue,” Anticancer Research, vol. 28, no. 6, pp. 3567–3572, 2008. View at Google Scholar · View at Scopus
  3. J. Feng, H. Liu, K. K. Bhakoo, L. Lu, and Z. Chen, “A metabonomic analysis of organ specific response to USPIO administration,” Biomaterials, vol. 32, no. 27, pp. 6558–6569, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Shahbazi-Gahrouei, S. M. Rizvi, M. A. Williams, and B. J. Allen, “In vitro studies of gadolinium-DTPA conjugated with monoclonal antibodies as cancer-specific magnetic resonance imaging contrast agents,” Australasian Physical and Engineering Sciences in Medicine, vol. 25, no. 1, pp. 31–38, 2002. View at Google Scholar · View at Scopus
  5. D. Shahbazi-Gahrouei, “Novel MR imaging contrast agents for cancer detection,” Journal of Research in Medical Sciences, vol. 14, no. 3, pp. 141–147, 2009. View at Google Scholar · View at Scopus
  6. C. Barcena, A. K. Sra, and J. M. Gao, “Application of magnetic nanoparticles in biomedicine,” in Nanoscale Magnetic Materials and Applications, pp. 591–626, 2009. View at Google Scholar
  7. M. V. Croce, M. T. Isla-Larrain, A. Capafons, M. R. Price, and A. Segal-Eiras, “Humoral immune response induced by the protein core of MUC1 mucin in pregnant and healthy women,” Breast Cancer Research and Treatment, vol. 69, no. 1, pp. 1–11, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Shahbazi-Gahrouei, M. Roufeh, and M. B. Tavakoli, “Gadolinium-diethylenetriaminepenta-acetic acid conjugated with monoclonal antibody C595 as new magnetic resonance imaging contrast agents for breast cancer (MCF-7) detection,” Iranian Biomedical Journal, vol. 10, no. 4, pp. 209–213, 2006. View at Google Scholar · View at Scopus
  9. K. L. Vigor, P. G. Kyrtatos, S. Minogue et al., “Nanoparticles functionalised with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells,” Biomaterials, vol. 31, no. 6, pp. 1307–1315, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Shahbazi-Gahrouei, M. Williams, S. Rizvi, and B. J. Allen, “In vivo studies of Gd-DTPA-monoclonal antibody and Gd-porphyrins: potential magnetic resonance imaging contrast agents for melanoma,” Journal of Magnetic Resonance Imaging, vol. 14, no. 2, pp. 169–174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Abdolahi, D. Shahbazi-Gahrouei, S. Laurent, C. Sermeus, F. Firozian, and B. J. Allend, “Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer,” Contrast Media and Molecular Imaging, vol. 8, no. 2, pp. 175–184, 2013. View at Google Scholar
  12. R. Forstner, M. W. Meissnitzer, A. Schlattau, and J. A. Spencer, “MRI in ovarian cancer,” Imaging in Medicine, vol. 4, no. 1, pp. 59–75, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Corot, P. Robert, J.-M. Idée, and M. Port, “Recent advances in iron oxide nanocrystal technology for medical imaging,” Advanced Drug Delivery Reviews, vol. 58, no. 14, pp. 1471–1504, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Feng, M. Ghazizadeh, H. Konishi, and T. Araki, “Expression of MUC1 and MUC2 mucin gene products in human ovarian carcinomas,” Japanese Journal of Clinical Oncology, vol. 32, no. 12, pp. 525–529, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Wang, J. Ma, F. Liu et al., “Expression of MUC1 in primary and metastatic human epithelial ovarian cancer and its therapeutic significance,” Gynecologic Oncology, vol. 105, no. 3, pp. 695–702, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Shahbazi-Gahrouei and M. Abdolahi, “A novel method for quantitative analysis of anti-MUC1 expressing ovarian cancer cell surface based on magnetic cell separation,” Journal of Medical Sciences, vol. 12, no. 8, pp. 256–266, 2012. View at Google Scholar
  17. D. Shahbazi-Gahrouei, M. Abdolahi, S. H. Zarkesh, S. Laurent, C. Sermeus, and C. Gruettner, “Functionalized magnetic nanoparticles for the detection and quantitative analysis of cell surface antigen,” Biomed Research International, vol. 2013, Article ID 349408, 9 pages, 2013. View at Publisher · View at Google Scholar
  18. A. H. Jacobs, H. Li, A. Winkeler et al., “Pet-based molecular imaging in neuroscience,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 30, no. 7, pp. 1051–1065, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Barrefelt, M. Saghafian, and R. Kuiper, “Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat,” International Journal of Nanomedicine, vol. 8, pp. 3241–3254, 2013. View at Google Scholar
  20. M. Di Marco, C. Sadun, M. Port, I. Guilbert, P. Couvreur, and C. Dubernet, “Physiochemical chracterization of ultra small superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents,” International Journal of Nanomedicine, vol. 2, no. 4, pp. 609–622, 2007. View at Google Scholar