Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of -tTF
Figure 2
Bioactivity of (RGD)3-tTF. (a) Clotting time. The clotting time of (RGD)3-tTF was similar to that of TF but significantly higher than that of RGD; there was no significant difference between (RGD)3-tTF and TF *, **. (b) Factor X (FX) activation. At 1 μmol/L or higher concentration, the activation FX by (RGD)3-tTF is comparable to that of free TF but significantly higher than that of RGD (*, **). (c) Specific binding to . (RGD)3-tTF binding with was significantly higher than that of RGD and TF (), and RGD binding with was significantly stronger than that of TF (*, **).