Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)₃-tTF

Figure 4

Fluorescence drugs accumulation in tumor tissue. In (RGD)₃-tTF mice, (a) Hoechst 33258-stained nucleus (blue); (b) (RGD)₃-tTF accumulated (red); merger of (a) and (b). In RGD mice, (d) Hoechst 33258-stained nucleus (blue); (e) RGD accumulated; (f) merger of (d) and (e). In TF mice, (g) Hoechst 33258-stained nucleus (blue); (h) no TF accumulation; (i) merger of (g) and (h) In saline mice, (j) Hoechst 33258-stained nucleus (blue); (k) no fluorescence; (l) merger of (j) and (k) (bar = 20 μm).

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