Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Table 3

Physicochemical parameters of naproxen sodium core, press-coated tablets, and enteric-coated tablets.

Formulation code	Weight variation (mg)	Thickness (mm)	Diameter (mm)	Hardness (kg/cm^2)	Friability (%)	Drug content (%)
NF1	251.24±2.24	4.01±0.02	8.01±0.02	4.09±0.59	0.63±0.03	95.27±2.03
NF2	500.31±2.26	4.62±0.02	12.88±0.02	6.48±0.59	0.53±0.02	92.36±1.91
NF3	501.19±2.19	4.78±0.02	12.03±0.02	6.05±0.59	0.25±0.03	96.37±2.09
NF4	502.15±2.21	4.82±0.02	12.08±0.02	6.54±0.67	0.28±0.02	93.99±1.48
NF5	502.07±2.26	4.86±0.02	12.92±0.02	6.47±0.59	0.20±0.02	95.61±1.95
NF6	503.15±2.23	4.57±0.02	12.81±0.02	6.34±0.67	0.46±0.02	94.49±1.86
NF7	500.68±2.28	4.53±0.02	12.86±0.02	6.25±0.59	0.29±0.02	94.41±1.90
NF8	501.63±2.28	4.57±0.02	12.74±0.02	6.59±0.67	0.23±0.02	95.61±1.96
NF9	502.03±2.26	4.59±0.02	12.94±0.02	6.35±0.67	0.22±0.01	94.36±2.03

Mean ± S.D. (𝑛=3).