The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics
Table 2
Complement system-based therapeutics. The clinical situation, principle of anticomplement therapy, and complement-based treatment are detailed.
Complement Deficiencies
Complement pathways involved
Protein
Associated gene
Complications
Alternative
Lectin
Classical
Activation
Recognition protein
X
MBL
MBL2
Infection in immunocompromised patient
X
H-ficolin
FCN3
Immune deficiency, necrotizing enterocolitis
X
C1q
C1QA, C1QB, C1QC
SLE-like syndrome, recurrent bacterial infections
X
MASP-2
MASP-2
Immune deficiency
X
C1r/s
C1R, C1S
SLE-like syndrome, recurrent bacterial infections
X
X
C2
C2
Autoimmune disease
X
Factor D
CFD
Meningococcal and encapsulated bacterial infections
X
Factor I
CFI
Encapsulated bacterial infections
Common Pathways
Structural protein
X
X
X
C3
C3
Bacterial infections, SLE-like syndrome
X
X
X
C4
C4A, C4B
SLE- like syndrome, encapsulated bacterial infections