The Ethanol Extract of the Inner Bark of Caesalpinia pyramidalis (Tul.) Reduces Urinary Bladder Damage during Cyclophosphamide-Induced Cystitis in Rats

Table 1

Effect of the ethanol extract of Caesalpinia pyramidalis (EECp) on the myeloperoxidase (MPO) activity and lipid peroxidation of lung and spleen of rats during cyclophosphamide (CP)-induced cystitis.

Tissue	Group	MPO (UMPO/mg of tissue)	MDA (pmol of MDA/mg of tissue)
Lung	Vehicle + Saline	6.6 ± 1.7	35.0 ± 8.5
	Vehicle + CP	14.6 ± 1.7^#	40.2 ± 5.5
	Mesna + CP	7.7 ± 1.6	13.1 ± 4.8*
	EECp (100 mg/kg) + CP	7.9 ± 2.5	52.8 ± 12.3
	EECp (200 mg/kg) + CP	6.4 ± 1.4*	17.3 ± 4.3*
	EECp (400 mg/kg) + CP	6.3 ± 1.2*	12.7 ± 5.6*
Spleen	Vehicle + Saline	16.3 ± 2.0	35.1 ± 7.2
	Vehicle + CP	20.7 ± 1.1	43.1 ± 10.7
	Mesna + CP	15.3 ± 1.7	18.9 ± 6.7
	EECp (100 mg/kg) + CP	17.2 ± 3.0	35.2 ± 16.1
	EECp (200 mg/kg) + CP	20.9 ± 2.7	22.8 ± 11.3
	EECp (400 mg/kg) + CP	27.1 ± 2.4	2.7 ± 2.0*

Rats were treated with EECp (100–400 mg/kg), mesna (40 mg/kg), or vehicle and injected with saline or CP (200 mg/kg). After 24 h of induction, the MPO activity and malondialdehyde (MDA) formation were determined in the lung or spleen tissues. Data are expressed as mean ± SEM for 𝑛=8 rats. ^#𝑃<0.05 versus respective vehicle + saline group; *𝑃<0.05 versus respective vehicle + CP group.