Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Figure 2

Chronic vasculopathy model. This diagram shows proposed interactions between pathophysiologic mechanisms in sickle cell disease that lead to chronic vasculopathy and organ injury. Key to mechanisms: Green arrows: balancing feedback loops, Red: abnormal vascular structure and function, orange: hemolysis, light blue: inflammation and oxidant stress, dark blue: ischemia and reperfusion, lavender: vasomotor, brown: coagulation, and gray: angiogenesis. See text for details.