Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice

Table 1

Effect of different doses of Diazoxide (mg/kg) on the various stages of seizures induced by Dichlorvos injection in mic (data are shown as percentage of mice, 𝑛=10). Stage 0: no abnormal behavior; Stage 1: excessive salivation, chewing, and pawing of whiskers and mouth; Stage 2: dazed appearance, intermittent motionlessness, tremor, and/or bobbing of the head; Stage 3: like Stage 2, with random and/or generalized jerks; Stage 4: intermittent rearing on hind legs with forepaws extended (with clonic jerking) without falling; Stage 5: like Stage 4, with falling to the side or rear; Stage 6: status epilepticus.

Treatment	Stage of seizures
	Stage 0	Stage 1–3	Stage 4–6
Dichlorvos	0	0	100
Diazoxide 1 + Dichlorvos	0	0	100
Diazoxide 2.5 + Dichlorvos	10	20	70
Diazoxide 5 + Dichlorvos	30	20	50
Diazoxide 10 + Dichlorvos	60	10	30
Diazoxide 20 + Dichlorvos	80	10	10