Research Article

One-Pot Synthesis of 2′-Aminobenzothiazolo-Arylmethyl-2-Naphthols Catalyzed by NBS under Solvent-Free Conditions

Table 2

Preparation of -aminobenzothiazolo-arylmethyl-2-naphtholsa.

EntryArTime
(min)
ProductsYield
(%)b
m.p.
(lit.) (°C)c

1C6H5104a94202–204
(204-205) [15]
24-Cl-C6H484b95209-210
(209-210) [15]
34-Me-C6H4104c92183-184
(182-183) [15]
44-F-C6H4104d98189-190
(188-189) [16]
54-NO2-C6H454e97188-189
(190-191) [16]
64-MeO-C6H4104f90172-173
(175-176) [16]
73-NO2-C6H484g93197–199
(198-199) [15]
82-Cl-C6H484h91185-186
(189-190) [16]
92,4-Cl2-C6H484i96203-204
(206-207) [16]
104-OH-3-MeO-C6H3154j88192–194
(194-195) [16]
113,4,5-MeO3C6H2154k92159-160

Reaction conditions: -naphthol (1 mmoL), aldehyde (1 mmoL), 2-amino-benzothiazole (1 mmoL), NBS (0.1 mmoL), 60°C, and neat.
Isolated yield.
Temperature value in the reference.