The Scientific World Journal / 2013 / Article / Tab 2 / Research Article
One-Pot Synthesis of 2′-Aminobenzothiazolo-Arylmethyl-2-Naphthols Catalyzed by NBS under Solvent-Free Conditions Table 2 Preparation of
-aminobenzothiazolo-arylmethyl-2-naphthols
a .
Entry Ar Time (min) Products Yield (%)b m.p. (lit.) (°C)c 1 C6 H5 10 4a 94 202–204 (204-205) [15 ] 2 4-Cl-C6 H4 8 4b 95 209-210 (209-210) [15 ] 3 4-Me-C6 H4 10 4c 92 183-184 (182-183) [15 ] 4 4-F-C6 H4 10 4d 98 189-190 (188-189) [16 ] 5 4-NO2 -C6 H4 5 4e 97 188-189 (190-191) [16 ] 6 4-MeO-C6 H4 10 4f 90 172-173 (175-176) [16 ] 7 3-NO2 -C6 H4 8 4g 93 197–199 (198-199) [15 ] 8 2-Cl-C6 H4 8 4h 91 185-186 (189-190) [16 ] 9 2,4-Cl2 -C6 H4 8 4i 96 203-204 (206-207) [16 ] 10 4-OH-3-MeO-C6 H3 15 4j 88 192–194 (194-195) [16 ] 11 3,4,5-MeO3 C6 H2 15 4k 92 159-160
Reaction conditions:
-naphthol (1 mmoL), aldehyde (1 mmoL), 2-amino-benzothiazole (1 mmoL), NBS (0.1 mmoL), 60°C, and neat.
Isolated yield.
Temperature value in the reference.