Alternative Splicing for Diseases, Cancers, Drugs, and Databases

Table 1

The bioinformatics resources related to alternative splicing (yrs 2001–2013)*.

AsMamDB [104]	An alternative splice database of mammals (website is unavailable)
PALS db [105]	Putative alternative splicing database
ASAP [106]	Alternative splicing annotation project (http://www.bioinformatics.ucla.edu/ASAP/)
EASED [107]	Extended alternatively spliced EST database
AVATAR [108]	Database for EST and mRNA
MAASE [109]	Alternative splicing database designed for splicing microarray (http://maase.genomics.purdue.edu/)
PolyA_DB [110]	Database for mRNA polyadenylation in mammalian
AltTrans [111]	Annotation for both alternative splicing and alternative polyadenylation
GRSDB [112]	Database of quadruplex forming G-rich sequences in alternative splicing sequences (http://bioinformatics.ramapo.edu/grsdb/)
HOLLYWOOD [113]	A comparative relational database of alternative splicing (http://hollywood.mit.edu/)
ASD [114]	A bioinformatics resource on alternative splicing
Splicy [115]	Prediction of alternative splicing from Affymetrix data
ASTALAVISTA [116]	Analysis of alternative splicing for custom datasets (http://genome.imim.es/astalavista/)
BIPASS [117]	Bioinformatics pipeline alternative splicing services
ECgene [118]	Alternative splicing database update (http://genome.ewha.ac.kr/ECgene/)
EuSplice [119]	A resource for splice signals and alternative splicing in eukaryotic genes (http://www.genome.com/products-1/integrated-genomics-resources/eusplice)
SpliceCenter [120]	A server for analysis of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies (http://discover.nci.nih.gov/splicecenter/)
ASPicDB [121]	Database for alternative splicing analysis (http://www.caspur.it/ASPicDB/)
The alternative splicing mutation database [122]	A hub for analyzing alternative splicing from mutational evidence
ProSAS [123]	Database for analyzing alternative splicing in the context of protein structures (http://www.bio.ifi.lmu.de/ProSAS/)
Splice-mediated Variants of Proteins (SpliVaP) [124]	Signatures for protein isoforms due to alternative splicing (http://www.bioinformatica.crs4.org/tools/dbs/splivap/)
AspAlt [125]	A interdatabase for comparative analysis of alternative transcription and splicing (http://www.genome.com/products-1/integrated-genomics-resources/products-integrated-genomics-resources-igr-aspalt)
ASTD [126]	Alternative splicing and transcript diversity database
TassDB2 [127]	A comprehensive database of subtle alternative splicing (http://www.tassdb.info/)
H-DBAS [128]	Human-transcriptome database for alternative splicing (http://h-invitational.jp/h-dbas/)
SPLOOCE [129]	Analysis server of human splicing variants (http://www.bioinformatics-brazil.org/splooce/)
APPRIS [130]	Annotation of human alternative splice isoforms (http://appris.bioinfo.cnio.es/)
SpliceAid 2 [131]	Database of human splicing factors expression data and RNA target motifs (http://www.introni.it/spliceaid.html)
TFClass [132]	Classification of human transcription factors (http://tfclass.bioinf.med.uni-goettingen.de/)

∗The websites for some resources without function currently are not provided.