Table 1: Water solubility, the partition coefficient (log P), and peritoneal to plasma drug area under the curve (AUC) ratio of intraperitoneal chemotherapeutic agents.

Chemotherapeutic agentMolecular weightWater solubilitylog P Peritoneal to plasma AUC ratio

Cisplatin300Good−2.1912
Carboplatin371Good1.0610–18
Oxaliplatin397Good1.7316
Paclitaxel854Poor3.541000
Docetaxel862Poor2.92181
5-Fluorouracil130Sparing-0.89367
Doxorubicin544Poor1.27474