NCK2 Is Significantly Associated with Opiates Addiction in African-Origin Men

Table 2

Association of the most significant SNPs in the NCK2 gene with the six substances dependence in African-origin sen.

Gene	SNP	Method	Alcohol	Cocaine	Marijuana	Nicotine	Opiates	Others
NCK2	rs2377339	Logistic regression	2.46𝐸−2	5.09𝐸−2	4.48𝐸−2	7.01𝐸−2	𝟏.𝟏𝟎𝐄−𝟕	3.84𝐸−3
		Standard allelic test	6.03𝐸−3	4.34𝐸−2	3.89𝐸−2	6.25𝐸−2	𝟏.𝟑𝟑𝐄−𝟏𝟏	1.78𝐸−3
	rs7589342	Logistic regression	2.84𝐸−1	8.79𝐸−1	9.35𝐸−1	8.60𝐸−1	1.45𝐸−4	4.26𝐸−1
		Standard allelic test	2.81𝐸−1	8.78𝐸−1	9.34𝐸−1	8.59𝐸−1	5.39𝐸−5	4.22𝐸−1
	rs12995333	Logistic regression	1.71𝐸−1	7.51𝐸−1	7.16𝐸−1	9.86𝐸−1	1.89𝐸−4	4.69𝐸−1
		Standard allelic test	1.68𝐸−1	7.51𝐸−1	7.15𝐸−1	9.86𝐸−1	7.82𝐸−5	4.67𝐸−1
	rs12053259	Logistic regression	1.39𝐸−1	9.43𝐸−1	7.42𝐸−1	9.01𝐸−1	2.31𝐸−4	4.86𝐸−1
		Standard allelic test	1.33𝐸−1	9.42𝐸−1	7.39𝐸−1	9𝐸−1	8.67𝐸−5	4.80𝐸−1
NCK2	—	KGG-logistic	1.83𝐸−1	8.15𝐸−1	5.92𝐸−1	9.56𝐸−3	𝟐.𝟕𝟎𝐄−𝟔	9.45𝐸−2
NCK2	—	KGG- Standard allelic test	1.41𝐸−1	8.16𝐸−1	4.83𝐸−1	8.71𝐸−3	𝟑.𝟏𝟐𝐄−𝟏𝟎	4.17𝐸−2