<i>In Vitro</i> Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Selective permeation parameters of micronized and nanonized alaptide through full-thickness pig ear skin from various media: nonsteady-state permeation flux (<svg height="13.6375" id="M44" style="vertical-align:-1.97925pt" version="1.1" viewbox="0 0 7.8874998 13.6375" width="7.8874998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>), corresponding lag time (<svg height="18.75" id="M45" style="vertical-align:-5.73161pt" version="1.1" viewbox="0 0 25.85 18.75" width="25.85" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.012,-0,0,-.012,11.388,15.637)"><path d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path></g><g transform="matrix(.012,-0,0,-.012,14.422,15.637)"><path d="M433 39l-85 -51q-27 0 -47 20q-16 16 -24 44q-5 -3 -24 -16.5t-27 -18.5t-23 -13.5t-25 -12t-19 -3.5q-52 0 -86 36.5t-34 85.5q0 71 81 99q128 43 155 65v17q0 54 -23 83.5t-62 29.5q-28 0 -45 -19t-29 -66q-7 -23 -29 -23q-15 0 -29 13t-14 30t31 40q25 19 68.5 40.5
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q0 -41 38 -68.5t94 -27.5q69 0 106.5 31t37.5 80q0 52 -45 71q-33 13 -98 13z" id="x67"></path></g>
</svg>), and apparent permeability coefficient (<svg height="18.3125" id="M46" style="vertical-align:-5.73163pt" version="1.1" viewbox="0 0 21 18.3125" width="21" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.113)"><path d="M764 650l-7 -26q-61 -10 -91.5 -22.5t-76.5 -48.5l-235 -184q104 -152 208 -276q31 -37 54.5 -48.5t68.5 -16.5l-7 -28h-156q-138 170 -213 284q-19 29 -33.5 35t-33.5 -7l-29 -173q-15 -75 -5.5 -90.5t74.5 -20.5l-5 -28h-260l7 28q58 5 74 21.5t30 89.5l70 378
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<g transform="matrix(.012,-0,0,-.012,13.25,15.188)"><path d="M570 304q0 -108 -87 -199q-40 -42 -94.5 -74t-105.5 -43q-41 0 -65 11l-29 -141q-9 -45 -1.5 -58t45.5 -16l26 -2l-5 -29l-241 -10l4 26q51 10 67.5 24t26.5 60l113 520q-54 -20 -89 -41l-7 26q38 28 105 53l11 49q20 25 77 58l8 -7l-17 -77q39 14 102 14q82 0 119 -36
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</svg>).

The Scientific World Journal

tab2

Table 2

Table 2: <i>In Vitro</i> Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations 

The Scientific World Journal

In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Table 2