Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice

Figure 5

Effect of borneol (BOR) and aspirin on leukocyte migration into the peritoneal cavity induced by carrageenan in mice. Groups of rats were pretreated with vehicle (control group), aspirin (200 mg/kg, p.o.), or BOR (5, 25, or 50 mg/kg, i.p.) 60 min before carrageenan (500 μg/cavity, 500 μL, i.p.)-induced peritonitis. Cell counts were performed at the time 4 h after the injection of carrageenan. Each value represents the mean ± S.E.M. Asterisks denote statistical significance, ^∗𝑃<0.5, ^∗∗𝑃<0.01, or ^∗∗∗𝑃<0.001 related to control group. ANOVA followed by Dunnett’s test (𝑛=6, per group).