Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice

Table 1

Effect of borneol and morphine on hot plate test in mice.

Groups	Dose (mg/kg)	Latency time (s)
		0.5 h	1 h	1.5 h	2 h
Vehicle	—	4.43 ± 0.48	7.52 ± 0.74	6.07 ± 0.70	6.52 ± 0.76
Borneol	5	7.07 ± 0.42	9.77 ± 1.28	8.48 ± 0.83	7.47 ± 0.41
	25	8.16 ± 0.89	7.58 ± 0.73	9.79 ± 0.48	8.27 ± 0.59
	50	9.86 ± 0.83*	9.18 ± 0.65	8.89 ± 0.91	9.84 ± 0.92*
Morphine	10	13.79 ± 2.52**	12.19 ± 1.67*	12.34 ± 1.75**	12.80 ± 1.17**

Values are mean ± SEM, 𝑛=6; *𝑃 < 0.05; **𝑃 < 0.01 significantly different from control (ANOVA followed by Dunnett’s test).