Cardiac Safety of Diclofenac at a Single Dose in Ram

Table 1

The effect of diclofenac (2.5 mg/kg, IM) treatment on cardiac damage markers in rams (mean ± SEM).

Parameters	0 (control) hour	6 hours	% alteration	𝑃 values
TI (ng/mL)	0.04±0.01	0.09±0.01	+125	𝑃<0.030
CK-MB (U/L)	131±6.42	160±11.9	+22.1	𝑃<0.080
LDH (U/L)	978±64.2	1212±107	+23.9	𝑃<0.018
AST (U/L)	54.3±4.72	102±17.5	+87.8	𝑃<0.038

TI: troponin I, CK-MB: creatine kinase-MB, LDH: lactate dehydrogenase, and AST: aspartate aminotransferase.