Cardiac Safety of Diclofenac at a Single Dose in Ram

Table 2

The effect of diclofenac (2.5 mg/kg, IM) treatment on the plasma concentrations of hepatic, renal, and muscular damage markers; lipid metabolism products; some biochemical parameters in rams (mean ± SEM).

Parameters	0 (control) hour	6 hour	% alteration	𝑃 values
ALP (U/L)	26.6±4.00	73.5±14.0	+176	𝑃<0.016
ALT (U/L)	13.3±1.35	19.0±2.48	+42.9	𝑃<0.038
GGT (U/L)	56.3±4.61	53.0±5.23	−5.86	𝑃>0.05
TP (g/dL)	6.73±0.17	6.76±0.16	+0.45	𝑃>0.05
Albumin (g/dL)	3.35±0.17	3.33±0.06	−0.60	𝑃>0.05
Creatinine (mg/dL)	0.83±0.07	0.89±0.10	+7.23	𝑃>0.05
BUN (mg/dL)	14.0±1.75	15.5±2.14	+10.7	𝑃>0.05
CK (U/L)	100±13.5	1690±369	+1590	𝑃<0.008
Cholesterol (mg/dL)	226±6.58	227±8.58	+0.44	𝑃>0.05
Triglyceride (mg/dL)	23.8±1.75	29.8±2.78	+25.2	𝑃>0.05
HDL (mg/dL)	30.8±4.40	36.3±4.49	+17.9	𝑃<0.011
LDL (mg/dL)	15.3±2.15	13.5±1.87	−11.8	𝑃<0.002
Glucose (mg/dL)	72.6±5.29	90.3±16.1	+24.4	𝑃>0.05
Phosphorus (mg/dL)	5.66±0.35	5.73±0.48	+1.24	𝑃>0.05

ALP: alkaline phosphatase, ALT: alanine aminotransferase, GGT: gamma glutamyltransferase, TP: total protein, CK: creatine kinase, BUN: blood urea nitrogen, HDL: high density lipoprotein, and LDL: low density lipoprotein.