Therapeutic Doses of Nonsteroidal Anti-Inflammatory Drugs Inhibit Osteosarcoma MG-63 Osteoblast-Like Cells Maturation, Viability, and Biomineralization Potential

Table 3

Percentage of cells with phagocyte capacity determinate by flow cytometry; treated with metamizole, dexketoprofen, ketorolac, and acetylsalicylic acid at doses of 1 and 10 𝜇M.

Treatment	% of cells phagocytes (mean value)	SD^a	𝑃 value
Control	98.89	1.5217
Metamizole 1 µM	78.20	1.9287	𝟎.𝟎𝟎𝟎^∗
Metamizole 10 µM	65.10	11.8528	𝟎.𝟎𝟑𝟖^∗
Dexketoprofen 1 µM	90.39	2.3180	𝟎.𝟎𝟎𝟏^∗
Dexketoprofen 10 µM	87.36	1.5534	𝟎.𝟎𝟎𝟏^∗
Ketorolac 1 µM	68.93	7.2037	𝟎.𝟎𝟏𝟕^∗
Ketorolac 10 µM	62.96	5.9877	𝟎.𝟎𝟎𝟕^∗
Acetylsalicylic Acid 1 µM	96.29	1.7235	0.035
Acetylsalicylic Acid 10 µM	88.47	1.9612	𝟎.𝟎𝟎𝟎^∗

aStandard deviation, ∗significant differences 𝑃<0.05.