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The Scientific World Journal
Volume 2013, Article ID 825375, 11 pages
Review Article

Hepatitis C Virus Infection: Looking for Interferon Free Regimens

Internal Medicine-Infectious Diseases Department, Hospital Son Llàtzer, Carretera de Manacor, Km 4, 07198 Palma de Mallorca, Spain

Received 7 February 2013; Accepted 4 March 2013

Academic Editors: H. C. Lin and S.-N. Lu

Copyright © 2013 J. González-Moreno and A. Payeras-Cifre. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent developments of new drugs' combinations are changing the treatment paradigm in hepatitis C virus infection. Due to the side effect profile of pegylated interferons, interferon-sparing regimens have become the main target in chronic hepatitis C treatment research. Recent proofs of concept studies have suggested that cure of chronic hepatitis C can be achieved without interferon. The purpose of this paper is to provide an overview of the clinical results recently reported for the treatment of hepatitis C virus infection with interferon-free regimens, focusing on the most promising new compounds and combinations.