Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

Table 3

Association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with immunological parameters in SLE.

Immunological parameters	141 patients		Anti-SSA/Ro60 (𝑛=60)			Anti-Ro52/TRIM21 (𝑛=39)
	𝑛	%	𝑛	%	OR (95% CI)	𝑛	%	OR (95% CI)
Anti-dsDNA	102	72.3	45	75.0	1.93 (0.64–5.79)	26	66.7	0.23 (0.07–0.73) ^b
Anti-Sm	15	10.6	7	11.6	1.05 (0.24–4.61)	5	12.8	1.2 (0.25–5.86)
Antiphospholipid	34	24.1	8	13.3	0.33 (0.10–1.08)	5	12.8	0.97 (0.24–3.94)
Anticardiolipin IgG/IgM	20	14.2	4	6.7	0.38 (0.09–1.65)	2	5.1	0.57 (0.08–3.88)
Anti-β 2glicoprotein IgG/IgM	20	14.2	6	10.0	0.52 (0.13–2.08)	4	10.2	1.07 (0.22–5.27)
Lupus anticoagulant^e	14	9.9	2	3.3		1	2.5
Low complement^a	106	75.2	48	80.0	4.61 (1.07–19.97) ^c	28	71.8	0.24 (0.05–1.09)
Low C3^a	89	63.1	41	68.3	2.44 (0.78–7.64)	24	61.5	0.52 (0.15–1.79)
Low C4^a	97	68.8	47	78.3	6.63 (1.63–26.94) ^d	27	69.2	0.25 (0.06–1.08)

Anti-SSA/Ro60 and anti-Ro52/TRIM21 analyzed together as independent variables by binary logistic regression analysis adjusted for sex and age (at diagnosis and time of analysis). Other autoantibodies also included as independent variable after selection by forward step procedure: ^aanti-dsDNA (positive association), ^b𝑃=0.013, ^c𝑃=0.041, ^d𝑃=0.008, and ^enot statistically analysed.