Isotretinoin Oil-Based Capsule Formulation Optimization

Table 2

The composition and dissolution parameters of isotretinoin oil-based capsules.

	𝑋1		𝑋2		𝑋3		𝐾	𝑛	𝑅	𝑌10min	𝑌30min	𝑌60min	𝑌90min
	Code	mg	Code	mg	Code	mg				%	%	%	%
F1	0.000	8	0.834	40	0.166	100	0.13	1.47	0.9920	4.9	20.1	58.2	78.7
F2	0.166	12	0.000	20	0.834	116	0.09	1.44	0.9781	2.2	12.6	32.7	74.1
F3	0.083	10	0.834	40	0.083	98	0.83	0.95	0.9336	6.4	13.8	50.6	74.4
F4	0.166	12	0.834	40	0.000	96	0.81	0.99	0.9831	6.8	23.8	51.9	74.5
F5	0.000	8	0.000	20	1.000	120	0.33	1.26	0.9789	7.7	20.4	57.4	82.0
F6	0.083	10	0.417	30	0.500	108	2.78	0.83	0.9954	17.2	54.6	89.4	102.5
F7	0.166	12	0.834	40	0.000	96	0.23	1.32	0.9823	6.7	22.8	51.5	73.5

(1) The total amount of isotretinoin oil-based capsule was 160 mg composed of drug 10 mg, vitamin E 2 mg, and other ingredients including beeswax (𝑋₁), hydrogenated coconut oil (𝑋₂), and soybean oil (𝑋₃) 148 mg.
(2) Release mechanism fitted by Korsmeyer-Peppas’ equation: 𝑀_𝑡/𝑀_∞=𝑘𝑡^𝑛, k, n, and r are release rate, diffusion exponent, and correlation coefficient.
(3) 𝑌_𝑖: responses, the drug release percentage at 10 min (𝑌_10min), 30 min (𝑌_30min), 60 min (𝑌_60min), and 90 min (𝑌_90min).
(4) The composition of each run was random and arranged according to the D-optimal model proved Design-Expert software.