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The Scientific World Journal
Volume 2013, Article ID 870468, 6 pages
http://dx.doi.org/10.1155/2013/870468
Research Article

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

1Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, CP 62790 Xochitepec, MOR, Mexico
2Unidad de Investigación Médica en Farmacología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc No. 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, DF, Mexico
3Instituto de Química, Universidad Nacional Autónoma de México, Del. Coyoacán 04510, DF, Mexico
4Universidad Tominaga Nakamoto, Luis Freg No. 6 y 12, Col. Lomas de Sotelo, CP 53390, Naucalpan de Juárez, Estado de México, Mexico
5Herbario Nacional de México (MEXU), Instituto de Biología, Universidad Nacional Autónoma de México, Apartado Postal 70-367, Del. Coyoacán 04510, DF, Mexico
6Unidad de Investigación Médica en Medicina Reproductiva, UMAE en Ginecología y Obstetricia No. 4, Instituto Mexicano del Seguro Social, Avenida Río Magdalena No. 289, Col. Tizapán San Ángel, CP 01090, Delegación Álvaro Obregón, DF, Mexico

Received 30 August 2013; Accepted 30 September 2013

Academic Editors: D. Benke, M. Bermejo, and N. Zohreh

Copyright © 2013 Maira Huerta-Reyes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Heteropterys cotinifolia (Malpighiaceae) has been used in traditional Mexican medicine mainly for the treatment of nervous disorders. However, the specific neuropharmacological activities responsible for this use remain to be defined. The present study evaluates the antidepressant and anxiolytic effects produced by the methanolic extract of Heteropterys cotinifolia and the influence of such effects on motor activity in ICR mice. Our results show that the methanolic extract of Heteropterys cotinifolia produces a dose-dependent antidepressant effect in the forced swimming test in mice at doses from 31 to 310 mg/kg, with no reduction of mice locomotion. However, no anxiolytic properties were observed. Our findings suggest that the main extract compounds identified as chlorogenic acid and rutin may be involved in the antidepressant effects. To our knowledge, the present study constitutes the first report of pharmacological and phytochemical data of Heteropterys cotinifolia. The presence of flavonoids in the methanolic extract of Heteropterys cotinifolia may also provide further data to characterize taxonomically this species in order to be distinguished from others species closely related and belonging to the same genus.