A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients

Table 2

Dosing results for heparin by weight category compared to recommendations in the literature.

Drugs	Weight category	Patients evaluated	Doses	Average dose	Median dose	Minimum	Maximum	Literature dose recommendation [17, 18]
	Underweight	0	0	—	—	—	—	VTE; 80 units/kg then 18 units/kg/hr; Maximum bolus 10,000 units; Maximum initial rate 1600 units/hr ASC; 60 units/kg then 12 units/kg/hr; Maximum bolus 5000 units. Max initial rate 1000 u/hr
	Normal weight	11	52	17.61	17.41	9.29	26.00
Heparin (units/kg/hr)	Overweight	17	39	12.23	11.97	6.00	18.00
	Obese	9	34	12.87	11.67	3.93	22.00
	Extremely obese	6	37	11.77	10.00	4.50	21.80