TY - JOUR A2 - Abdel-Dayem, H. A2 - Smith, T. A2 - Kao, C.-H. AU - Cistaro, Angelina AU - Quartuccio, Natale AU - Mojtahedi, Alireza AU - Fania, Piercarlo AU - Filosso, Pier Luigi AU - Cucinotta, Mariapaola AU - Campennì, Alfredo AU - Ficola, Umberto AU - Baldari, Sergio PY - 2013 DA - 2013/10/09 TI - Is %ΔSUVmax a Useful Indicator of Survival in Patients with Advanced Nonsmall-Cell Lung Cancer? SP - 910957 VL - 2013 AB - Purpose. To investigate the impact of the maximum standardized uptake value (SUVmax), size of primary lung lesion, and %ΔSUVmax on outcome (overall survival (OS) and 2-year disease-free survival (2-year DFS)) of patients with advanced nonsmall-cell lung cancer (NSCLC). Materials and Methods. 86 stage III-IV NSCLC patients underwent 18 F-FDGPET/CT, before and after chemotherapy, and were classified into subgroups according to the response criteria of the European Organization for Research and Treatment of Cancer. SUVmax values and tumor size with the best prognostic significance were searched. Correlation between the SUVmax value and the initial response to therapy (best response) and the relationship between %ΔSUVmax and OS were assessed. Results. In patients in PD (20/86), the average pretreatment SUVmax was 11.8±5.23, and the mean size of the primary lesion was 43.35mm±16.63. In SD, PR, and CR patients (66/86), the average pretreatment SUVmax was 12.7±8.05, and the mean size of the primary lesion was 41.6mm±21.15. Correlation was identified only for %ΔSUVmax; patients with PD (ΔSUVmax > +25%) showed a worse OS than patients with ΔSUVmax < +25% (CR, PR, and SD) (P=0.0235). Conclusions. In stage III-IV NSCLC, among the assessed factors, only %ΔSUVmax may be considered as a useful prognostic factor. SN - 2356-6140 UR - https://doi.org/10.1155/2013/910957 DO - 10.1155/2013/910957 JF - The Scientific World Journal PB - Hindawi Publishing Corporation KW - ER -