Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2013, Article ID 917082, 5 pages
http://dx.doi.org/10.1155/2013/917082
Research Article

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats

1Cellular & Molecular Research Center, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran
2Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran
3Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Pursina Avenue, Tehran, Iran
4Department of Physiology, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran

Received 11 August 2013; Accepted 5 September 2013

Academic Editors: P. Fabio, P. Schwenkreis, and Ü. Tan

Copyright © 2013 H. Rasoolijazi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Kar, “Role of amyloid β peptides in the regulation of central cholinergic function and its relevance to Alzheimer's disease pathology,” Drug Development Research, vol. 56, no. 2, pp. 248–263, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. M. S. Parihar and T. Hemnani, “Alzheimer's disease pathogenesis and therapeutic interventions,” Journal of Clinical Neuroscience, vol. 11, no. 5, pp. 456–467, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Jonsson, H. Stefansson, S. Steinberg et al., “Variant of TREM2 associated with the risk of Alzheimer's disease,” The New England Journal of Medicine, vol. 368, pp. 107–116, 2013. View at Google Scholar
  4. S. Salloway, J. Mintzer, M. F. Weiner, and J. L. Cummings, “Disease-modifying therapies in Alzheimer's disease,” Alzheimer's and Dementia, vol. 4, no. 2, pp. 65–79, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. P. G. Kehoe, “Angiotensins and Alzheimer's disease: a bench to bedside overview,” Alzheimer's Research & Therapy, vol. 1, pp. 1–8, 2009. View at Google Scholar
  6. A. B. Clippingdale, J. D. Wade, and C. J. Barrow, “The amyloid-β peptide and its role in Alzheimer's disease,” Journal of Peptide Science, vol. 7, no. 5, pp. 227–249, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Praticò, C. M. Clark, F. Liun, V. Y.-M. Lee, and J. Q. Trojanowski, “Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease,” Archives of Neurology, vol. 59, no. 6, pp. 972–976, 2002. View at Google Scholar · View at Scopus
  8. Y. Gilgun-Sherki, E. Melamed, and D. Offen, “Antioxidant treatment in Alzheimer's disease: current state,” Journal of Molecular Neuroscience, vol. 21, no. 1, pp. 1–11, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Shabtay, H. Sharabani, Z. Barvish et al., “Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia,” Oncology, vol. 75, no. 3-4, pp. 203–214, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Munné-Bosch and L. Alegre, “Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary,” Plant Physiology, vol. 125, no. 2, pp. 1094–1102, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Satoh, K. Kosaka, K. Itoh et al., “Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1,” Journal of Neurochemistry, vol. 104, no. 4, pp. 1116–1131, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Azad, H. Rasoolijazi, M. T. Joghataie, and S. Soleimani, “Neuroprotective effects of carnosic acid in an experimental model of Alzheimer's disease in rats,” Cell Journal, vol. 13, no. 1, pp. 39–44, 2011. View at Google Scholar · View at Scopus
  13. R. H. Silva, L. F. Felicio, and R. Frussa-Filho, “Ganglioside GM1 attenuates scopolamine-induced amnesia in rats and mice,” Psychopharmacology, vol. 141, no. 2, pp. 111–117, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. J. He, Y.-M. Chen, J.-H. Wang, and Y.-Y. Ma, “Effect of Co-administration of morphine and cholinergic antagonists on Y-maze spatial recognition memory retrieval and locomotor activity in mice,” Zoological Research, vol. 6, pp. 613–620, 2008. View at Google Scholar
  15. A. Nitta, R. Murai, N. Suzuki et al., “Diabetic neuropathies in brain are induced by deficiency of BDNF,” Neurotoxicology and Teratology, vol. 24, no. 5, pp. 695–701, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Roghani, M. T. Joghataie, M. R. Jalali, and T. Baluchnejadmojarad, “Time course of changes in passive avoidance and Y-maze performance in male diabetic rats,” Iranian Biomedical Journal, vol. 10, no. 2, pp. 99–104, 2006. View at Google Scholar · View at Scopus
  17. L. C. Schmued and K. J. Hopkins, “Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration,” Brain Research, vol. 874, no. 2, pp. 123–130, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Duch, “Therapeutic applications of computer models of brain activity for Alzheimer disease,” Journal of Medical Informatics and Technologies, vol. 5, pp. 27–34, 2000. View at Google Scholar
  19. J.-J. Yan, J.-Y. Cho, H.-S. Kim et al., “Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid,” British Journal of Pharmacology, vol. 133, no. 1, pp. 89–96, 2001. View at Google Scholar · View at Scopus
  20. H. Rasoolijazi, M. T. Joghataie, M. Roghani, and M. Nobakht, “The beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of Alzheimer's disease in rat: a behavioral analysis,” Iranian Biomedical Journal, vol. 11, no. 4, pp. 237–243, 2007. View at Google Scholar · View at Scopus
  21. R. H. Silva, V. C. Abílio, A. L. Takatsu et al., “Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice,” Neuropharmacology, vol. 46, no. 6, pp. 895–903, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Erkan, G. Ayranci, and E. Ayranci, “Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol,” Food Chemistry, vol. 110, no. 1, pp. 76–82, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Svobodová, J. Psotová, and D. Walterová, “Natural phenolics in the prevention of UV-induced skin damage. A review,” Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, vol. 147, pp. 137–145, 2003. View at Google Scholar
  24. D. Poeckel, C. Greiner, M. Verhoff et al., “Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes,” Biochemical Pharmacology, vol. 76, no. 1, pp. 91–97, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Kosaka and T. Yokoi, “Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98g human glioblastoma cells,” Biological and Pharmaceutical Bulletin, vol. 26, no. 11, pp. 1620–1622, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Ninomiya, H. Matsuda, H. Shimoda et al., “Carnosic acid, a new class of lipid absorption inhibitor from sage,” Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 8, pp. 1943–1946, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Rezaie, S. R. McKercher, K. Kosaka et al., “Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration,” Investigative Ophthalmology & Visual Science, vol. 53, pp. 7847–7854, 2012. View at Google Scholar