The Scientific World Journal / 2013 / Article / Tab 1

Review Article

Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma

Table 1

Synthetic MMP-9 inhibitors.

NameType of drugSpecifity of the inhibitionReference

BatimastatPeptidomimeticMMP-1, -2, -3, -7, -9[40]
MarimastatPeptidomimeticBroad spectrum[41]
CTTHWGFTLCPeptidomimeticMMP-2, -9[38]
CGYGRFSPPCPeptidomimeticMMP-2, -9[42]
CRVYGPYLLC PeptidomimeticMMP-2, -9[42]
ABT-518 PeptidomimeticMMP-2, -9[43]
GRENYHGCTTHWGFTLCPeptidomimeticMMP-2, -9[39]
IlomastatPeptidomimeticBroad spectrum[44]
TanovastatNonpeptidomimeticMMP-2, -3, -9[45]
PrinovastatNonpeptidomimeticMMP-2, -3, -7, -9, -13[46]
BMS-275291 NonpeptidomimeticMMP-2, -9[47]
Metastat (COL-3) Chemically modified tetracyclineMMP-1, -2, -8, -9, -13[48]
CMT-3Chemically modified tetracyclineMMP-8, -9, -MT1-MMP[49]
DoxycyclineChemically modified tetracyclineMMP-1, -2, -3, -8, -9, -10, -13[50]
SB-3CT Reform proenzyme structureMMP-2, -9[51]
BisphosphonatesAnalogues of inorganic pyrophosphateMMP-1, -2, -7, -9, MT1-, MT2-MMP[52]
ChlorhexidineBisbiguanide antisepticMMP-2, -8, -9[53]
LetrozoleNonsteroidal inhibitor of aromataseMMP-2, -9[54]
PCK 3145 Synthetic peptide based on PSP94MMP-9[55]

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