The Scientific World Journal / 2013 / Article / Tab 1

Review Article

Efficacy of Memantine, Donepezil, or Their Association in Moderate-Severe Alzheimer’s Disease: A Review of Clinical Trials

Table 1

Inclusion and exclusion criteria of papers selected for this review.

CriterionReason of inclusionReason of exclusion

Population Qualifying disease: AD (diagnosed with established criteria, e.g., DSM-IV and NINCDS-ADRDA)
Any severity of disease at baseline
Community-/nursing-home-dwelling residents

Perspective of the studyProspective (concurrent)
(nonconcurrent, historical)

Type of the studyRCT (open label or blinded)
Crossover trials with a washout period between treatments
Non-randomised CCT:
case control
cross sectional
noncomparative study

Language EnglishAll others

Study duration Any None

Sample size AnyNone

Intervention/treatmentsAny dose of
(i) donepezil
(ii) memantine

Control intervention/treatmentsPlacebo/usual care 
Any of the above interventions

DSM-IV: Diagnostic and Statistical Manual of Mental Disorders; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke and the AD and Related Disorders Association; CCT: controlled clinical trial.

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