Feature-Based Classification of Amino Acid Substitutions outside Conserved Functional Protein Domains

Table 4

Performance statistics of PolyPhen-2, SIFT, and ISM binary classification of AASs outside CFDs.

	Accuracy	Precision	Sensitivity	Specificity	NPV	AUC
PolyPhen-2 (𝑝=0.863)	0.52	0.31	0.39	0.58	0.67	0.49
SIFT (𝑝=0.236)	0.57	0.37	0.51	0.59	0.72	0.55
ISM (𝑝<0.001)	0.69	0.51	0.65	0.70	0.81	0.68