Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
Figure 2
Morphological changes of C6-TK and C6-sr39TK cells 72 hours after ganciclovir (GCV) administration (×200). As compared with control C6 cells (a), C6-TK (b) and C6-sr39TK cells (c), especially the latter, showed evident morphological changes that were characteristic of growth inhibition/cellular death after GCV treatment: cells became round and shrunk, lost their protuberances, and detached from the floor of culture flasks.