Research Article

Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers

Figure 3

The shape of the model membrane with cholesterol. (a) Initial planar bilayer. (b) Final curved bilayer after 20 μs of simulation. The scales of the panels (a) and (b) are shown. DOPC lipids are black, DOPS lipids are gray, and cholesterol molecules are white and are shown in surface representation. Phosphate groups of the lipids are shown as large spheres. Vertical lines show the extents of the periodic simulation box in dimension. The system without cholesterol looks very similar.
965230.fig.003a
(a)
965230.fig.003b
(b)