Research Article

Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination

Table 11

The distribution of Spearman ( ) correlation coefficients, two-tailed model for significant associations ( ) between the immunohistochemical expressions of ECM genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 and epithelial markers EGFR, VEGF, KI-67, P53, and Bcl-2 in CRC ( ).

FN-1ITGA-3ITGB-5MMP-2MMP-9EGFRVEGFKI-67P53Bcl-2

FN11
ITGA-310.480.650.74
ITGB-50.4810.430.42
MMP-21−0.20−0.01
MMP-90.650.4310.760.300.22
EGFR0.740.420.7610.370.33
VEGF10.33
KI-670.300.3710.87
P53−0.190.220.330.871
Bcl-20.331

0 = no correlation; 0–0.25 = weak; 0.25–0.50 = regular; 0.50–0.75 = moderate; >0.75 = strong; 1 = perfect correlation.