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The Scientific World Journal
Volume 2014, Article ID 121679, 8 pages
http://dx.doi.org/10.1155/2014/121679
Research Article

C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis

1Division of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, Brazil
2Division of Gerontological Nursing, Faculty of Nursing, Federal University of Rio Grande do Sul (UFRGS), São Manoel Street 963, 90620-110 Porto Alegre, RS, Brazil
3Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2.040, 90035-903 Porto Alegre, RS, Brazil

Received 23 August 2013; Accepted 21 October 2013; Published 22 January 2014

Academic Editors: P. Trombley and Y. Yoshiyama

Copyright © 2014 Liara Rizzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. W. Sullivan, I. J. Sarembock, and J. Linden, “The role of inflammation in vascular diseases,” Journal of Leukocyte Biology, vol. 67, no. 5, pp. 591–602, 2000. View at Google Scholar · View at Scopus
  2. H.-K. Kuo, C.-J. Yen, C.-H. Chang, C.-K. Kuo, J.-H. Chen, and F. Sorond, “Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis,” The Lancet Neurology, vol. 4, no. 6, pp. 371–380, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Amor, F. Puentes, D. Baker, and P. van der Valk, “Inflammation in neurodegenerative diseases,” Immunology, vol. 129, no. 2, pp. 154–169, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. M. Kennedy and N. Raz, “Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed,” Neuropsychologia, vol. 47, no. 3, pp. 916–927, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. T. A. Pearson, G. A. Mensah, R. W. Alexander et al., “Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association,” Circulation, vol. 107, no. 3, pp. 499–511, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. J. Engelhart, M. I. Geerlings, J. Meijer et al., “Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study,” Archives of Neurology, vol. 61, no. 5, pp. 668–672, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Komulainen, T. A. Lakka, M. Kivipelto et al., “Serum high sensitivity C-reactive protein and cognitive function in elderly women,” Age and Ageing, vol. 36, no. 4, pp. 443–448, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Schmidt, H. Schmidt, J. D. Curb, K. Masaki, L. R. White, and L. J. Launer, “Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging study,” Annals of Neurology, vol. 52, no. 2, pp. 168–174, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. E. J. van Dijk, N. D. Prins, S. E. Vermeer et al., “C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan study,” Circulation, vol. 112, no. 6, pp. 900–905, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. C. L. Satizabal, Y. C. Zhu, B. Mazoyer, C. Dufouil, and C. Tzourio, “Circulating IL-6 and CRP are associated with MRI findings in the elderly: the 3C-Dijon Study,” Neurology, vol. 78, no. 10, pp. 720–727, 2012. View at Publisher · View at Google Scholar
  11. P. M. Ridker, “Clinical application of C-reactive protein for cardiovascular disease detection and prevention,” Circulation, vol. 107, no. 3, pp. 363–369, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. H.-K. Kuo and L. A. Lipsitz, “Cerebral white matter changes and geriatric syndromes: is there a link?” Journals of Gerontology A, vol. 59, no. 8, pp. 818–826, 2004. View at Google Scholar · View at Scopus
  13. J. A. Smith, S. T. Turner, Y. V. Sun et al., “Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA study,” BMC Medical Genomics, vol. 2, article 16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. F.-E. de Leeuw, J. C. de Groot, E. Achten et al., “Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan study,” Journal of Neurology Neurosurgery and Psychiatry, vol. 70, no. 1, pp. 9–14, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. V. G. Young, G. M. Halliday, and J. J. Kril, “Neuropathologic correlates of white matter hyperintensities,” Neurology, vol. 71, no. 11, pp. 804–811, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. E. Grueter and U. G. Schulz, “Age-related cerebral white matter disease (leukoaraiosis): a review,” Postgraduate Medical Journal, vol. 88, no. 1036, pp. 79–87, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Raz, Y. Yang, C. L. Dahle, and S. Land, “Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants,” Biochimica et Biophysica Acta, vol. 1822, no. 3, pp. 361–369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Umemura, T. Kawamura, H. Umegaki et al., “Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 82, no. 11, pp. 1186–1194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Fazekas, J. B. Chawluk, and A. Alavi, “MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging,” American Journal of Roentgenology, vol. 149, no. 2, pp. 351–356, 1987. View at Google Scholar · View at Scopus
  20. M. F. Folstein, S. E. Folstein, and P. R. McHugh, “'Mini mental state'. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  21. P. H. F. Bertolucci BS and S. R. Campacci, “O mini-exame do estado mental em uma população geral: impacto da escolaridade,” Arquivos de Neuro-Psiquiatria, vol. 52, no. 1, pp. 1–7, 1994. View at Publisher · View at Google Scholar
  22. J. A. Yesavage, T. L. Brink, and T. L. Rose, “Development and validation of a geriatric depression screening scale: a preliminary report,” Journal of Psychiatric Research, vol. 17, no. 1, pp. 37–49, 1982. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Almeida and S. Almeida, “Confiabilidade da versão brasileira da Escala de Depressão em Geriatria (GDS) versão reduzida,” Arquivos de Neuro-Psiquiatria, vol. 57, no. 2, pp. 421–426, 1999. View at Publisher · View at Google Scholar
  24. K. F. Hoth, A. P. Haley, J. Gunstad et al., “Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease,” Journal of the American Geriatrics Society, vol. 56, no. 10, pp. 1898–1903, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Gunstad, L. Bausserman, R. H. Paul et al., “C-reactive protein, but not homocysteine, is related to cognitive dysfunction in older adults with cardiovascular disease,” Journal of Clinical Neuroscience, vol. 13, no. 5, pp. 540–546, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. M. G. Dik, C. Jonker, C. E. Hack, J. H. Smit, H. C. Comijs, and P. Eikelenboom, “Serum inflammatory proteins and cognitive decline in older persons,” Neurology, vol. 64, no. 8, pp. 1371–1377, 2005. View at Google Scholar · View at Scopus
  27. J. Weuve, P. M. Ridker, N. R. Cook, J. E. Buring, and F. Grodstein, “High-sensitivity C-reactive protein and cognitive function in older women,” Epidemiology, vol. 17, no. 2, pp. 183–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. C. E. Teunissen, M. P. J. van Boxtel, H. Bosma et al., “Inflammation markers in relation to cognition in a healthy aging population,” Journal of Neuroimmunology, vol. 134, no. 1-2, pp. 142–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Fornage, Y. A. Chiang, E. S. Omeara et al., “Biomarkers of inflammation and MRI-defined small vessel disease of the brain: the cardiovascular health study,” Stroke, vol. 39, no. 7, pp. 1952–1959, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Wersching, T. Duning, H. Lohmann et al., “Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function,” Neurology, vol. 74, no. 13, pp. 1022–1029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. K. F. Hoth, D. F. Tate, A. Poppas et al., “Endothelial function and white matter hyperintensities in older adults with cardiovascular disease,” Stroke, vol. 38, no. 2, pp. 308–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Schmidt, H. Schmidt, M. Pichler et al., “C-reactive protein, carotid atherosclerosis, and cerebral small-vessel disease: results of the austrian stroke prevention study,” Stroke, vol. 37, no. 12, pp. 2910–2916, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Wada, H. Nagasawa, K. Kurita et al., “Cerebral small vessel disease and C-reactive protein: results of a cross-sectional study in community-based Japanese elderly,” Journal of the Neurological Sciences, vol. 264, no. 1-2, pp. 43–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. A. L. Jefferson, J. M. Massaro, P. A. Wolf et al., “Inflammatory biomarkers are associated with total brain volume: the Framingham Heart study,” Neurology, vol. 68, no. 13, pp. 1032–1038, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. L. T. Grinberg and D. R. Thal, “Vascular pathology in the aged human brain,” Acta Neuropathologica, vol. 119, no. 3, pp. 277–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. I. L. H. Knottnerus, H. Ten Cate, J. Lodder, F. Kessels, and R. J. van Oostenbrugge, “Endothelial dysfunction in lacunar stroke: a systematic review,” Cerebrovascular Diseases, vol. 27, no. 5, pp. 519–526, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. D. W. Hedges, T. J. Farrer, and B. L. Brown, “Association between C-reactive protein and cognitive deficits in elderly men and women: a meta-analysis,” International Psychogeriatrics, vol. 24, no. 9, pp. 1387–1392, 2012. View at Publisher · View at Google Scholar
  38. C. L. Wassel, E. Barrett-Connor, and G. A. Laughlin, “Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: the Rancho Bernardo study,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 10, pp. 4748–4755, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. P. L. McGeer and E. G. McGeer, “Inflammation, autotoxicity and Alzheimer disease,” Neurobiology of Aging, vol. 22, no. 6, pp. 799–809, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. M. G. de Simoni, A. de Luigi, L. Gemma, M. Sironi, A. Manfridi, and P. Ghezzi, “Modulation of systemic interleukin-6 induction by central interleukin-1,” American Journal of Physiology, vol. 265, no. 4, part 2, pp. R739–R742, 1993. View at Google Scholar · View at Scopus
  41. E. M. Macy, T. E. Hayes, and R. P. Tracy, “Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications,” Clinical Chemistry, vol. 43, no. 1, pp. 52–58, 1997. View at Google Scholar · View at Scopus