The Scientific World Journal / 2014 / Article / Fig 6

Research Article

Andrographolide Inhibits Nuclear Factor-B Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells

Figure 6

Diagram of the hypothetical inhibitory mechanism of andrographolide-induced effects in TNF- -stimulated VSMCs. TNF- triggers the expression of iNOS through I B -(I B -p65) and I B -independent (JNK-Akt-p65) pathways.