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The Scientific World Journal
Volume 2014, Article ID 140736, 7 pages
http://dx.doi.org/10.1155/2014/140736
Research Article

Prognostic Value of C-Reactive Protein, Leukocytes, and Vitamin D in Severe Chronic Obstructive Pulmonary Disease

1Section of Respiratory Medicine, Hvidovre University Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
2Department of Respiratory Medicine, Odense University Hospital, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark
3Respiratory and Allergy Research Group, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK
4Section of Social Medicine, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark

Received 20 August 2013; Accepted 23 October 2013; Published 21 January 2014

Academic Editors: R. Álvarez-Sala and D. Berry

Copyright © 2014 Mia Moberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. G. N. Agusti, “COPD, a multicomponent disease: implications for management,” Respiratory Medicine, vol. 99, no. 6, pp. 670–682, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. R. Rosenberg and R. Kalhan, “Biomarkers in chronic obstructive pulmonary disease,” Translational Research, vol. 159, no. 4, pp. 228–237, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Q. Gan, S. F. P. Man, A. Senthilselvan, and D. D. Sin, “Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis,” Thorax, vol. 59, no. 7, pp. 574–580, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Dahl, J. Vestbo, P. Lange, S. E. Bojesen, A. Tybjærg-Hansen, and B. G. Nordestgaard, “C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 3, pp. 250–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Thomsen, M. Dahl, P. Lange, J. Vestbo, and B. G. Nordestgaard, “Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 186, no. 10, pp. 982–988, 2012. View at Publisher · View at Google Scholar
  6. M. L. Melamed, E. D. Michos, W. Post, and B. Astor, “25-hydroxyvitamin D levels and the risk of mortality in the general population,” Archives of Internal Medicine, vol. 168, no. 15, pp. 1629–1637, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Skaaby, L. L. Husemoen, C. Pisinger et al., “Vitamin D status and cause-specific mortality: a general population study,” PLoS ONE, vol. 7, no. 12, Article ID e52423, 2012. View at Publisher · View at Google Scholar
  8. W. Janssens, R. Bouillon, B. Claes et al., “Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene,” Thorax, vol. 65, no. 3, pp. 215–220, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Vestbo and S. Rennard, “Chronic obstructive pulmonary disease biomarker(s) for disease activity needed—urgently,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 7, pp. 863–864, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. J. E. A. Williams, R. H. Green, V. Warrington, M. C. Steiner, M. D. L. Morgan, and S. J. Singh, “Development of the i-BODE: validation of the incremental shuttle walking test within the BODE index,” Respiratory Medicine, vol. 106, no. 3, pp. 390–396, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. B. R. Celli, C. G. Cote, J. M. Marin et al., “The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease,” The New England Journal of Medicine, vol. 350, no. 10, pp. 1005–1012, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. K.-C. Ong, A. Earnest, and S.-J. Lu, “A multidimensional grading system (BODE index) as predictor of hospitalization for COPD,” Chest, vol. 128, no. 6, pp. 3810–3816, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. J. M. Marin, S. J. Carrizo, C. Casanova et al., “Prediction of risk of COPD exacerbations by the BODE index,” Respiratory Medicine, vol. 103, no. 3, pp. 373–378, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. J. Singh, M. D. Morgan, S. Scott, D. Walters, and A. E. Hardman, “Development of a shuttle walking test of disability in patients with chronic airways obstruction,” Thorax, vol. 47, no. 12, pp. 1019–1024, 1992. View at Google Scholar · View at Scopus
  15. M. Thomsen, T. Ingebrigtsen, J. Marott et al., “Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease,” The Journal of the American Medical Association, vol. 309, no. 22, pp. 2353–2361, 2013. View at Publisher · View at Google Scholar
  16. A. Agusti, L. D. Edwards, S. I. Rennard et al., “Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype,” PLoS ONE, vol. 7, no. 5, Article ID e37483, 2012. View at Publisher · View at Google Scholar
  17. B. R. Celli, N. Locantore, J. Yates et al., “Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 10, pp. 1065–1072, 2012. View at Publisher · View at Google Scholar
  18. C. Garcia-Polo, B. Alcazar-Navarrete, L. A. Ruiz-Iturriaga et al., “Factors associated with high healthcare resource utilisation among COPD patients,” Respiratory Medicine, vol. 106, no. 12, pp. 1734–1742, 2012. View at Publisher · View at Google Scholar
  19. E. Gaki, K. Kontogianni, A. I. Papaioannou et al., “Associations between BODE index and systemic inflammatory biomarkers in COPD,” COPD: Journal of Chronic Obstructive Pulmonary Disease, vol. 8, no. 6, pp. 408–413, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. S.-F. Liu, C.-C. Wang, C.-H. Chin, Y.-C. Chen, and M.-C. Lin, “High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD,” Archivos de Bronconeumologia, vol. 47, no. 9, pp. 427–432, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. S. F. Man, J. E. Connett, N. R. Anthonisen, R. A. Wise, D. P. Tashkin, and D. D. Sin, “C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease,” Thorax, vol. 61, no. 10, pp. 849–853, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. J. P. de Torres, E. Cordoba-Lanus, C. López-Aguilar et al., “C-reactive protein levels and clinically important predictive outcomes in stable COPD patients,” European Respiratory Journal, vol. 27, no. 5, pp. 902–907, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. J. P. de Torres, V. Pinto-Plata, C. Casanova et al., “C-reactive protein levels and survival in patients with moderate to very severe COPD,” Chest, vol. 133, no. 6, pp. 1336–1343, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Karadag, S. Kirdar, A. B. Karul, and E. Ceylan, “The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease,” European Journal of Internal Medicine, vol. 19, no. 2, pp. 104–108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Dickens, B. E. Miller, L. D. Edwards, E. K. Silverman, D. A. Lomas, and R. Tal-Singer, “COPD association and repeatability of blood biomarkers in the ECLIPSE cohort,” Respiratory Research, vol. 12, article 146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. D. B. Holmgaard, L. H. Mygind, I. L. Titlestad et al., “Serum vitamin D in patients with chronic obstructive lung disease does not correlate with mortality—results from a 10-year prospective cohort study,” PLoS ONE, vol. 8, no. 1, Article ID e53670, 2013. View at Publisher · View at Google Scholar
  27. M. S. Hutchinson, G. Grimnes, R. M. Joakimsen, Y. Figenschau, and R. Jorde, “Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study,” European Journal of Endocrinology, vol. 162, no. 5, pp. 935–942, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. A. A. Ginde, R. Scragg, R. S. Schwartz, and C. A. Camargo Jr., “Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults,” Journal of the American Geriatrics Society, vol. 57, no. 9, pp. 1595–1603, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Ringbaek, G. Martinez, A. Durakovic et al., “Vitamin D status in patients with chronic obstructive pulmonary disease who participate in pulmonary rehabilitation,” Journal of Cardiopulmonary Rehabilitation and Prevention, vol. 31, no. 4, pp. 261–267, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. P. N. Black and R. Scragg, “Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination Survey,” Chest, vol. 128, no. 6, pp. 3792–3798, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. A. A. Ginde, J. M. Mansbach, and C. A. Camargo Jr., “Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey,” Archives of Internal Medicine, vol. 169, no. 4, pp. 384–390, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Lehouck, C. Mathieu, C. Carremans et al., “High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial,” Annals of Internal Medicine, vol. 156, no. 2, pp. 105–114, 2012. View at Google Scholar · View at Scopus
  33. P. Pludowski, M. F. Holick, S. Pilz et al., “Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence,” Autoimmunity Reviews, vol. 12, no. 10, pp. 976–989, 2013. View at Publisher · View at Google Scholar