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The Scientific World Journal
Volume 2014, Article ID 156464, 4 pages
Research Article

Effects of Isotretinoin on the Platelet Counts and the Mean Platelet Volume in Patients with Acne Vulgaris

1Department of Dermatology, Konya Training and Research Hospital, Meram, Konya 42023, Turkey
2Department of Hematology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya 42080, Turkey

Received 29 August 2013; Accepted 16 December 2013; Published 29 January 2014

Academic Editors: H. Fujita and G. A. Vena

Copyright © 2014 Arzu Ataseven and Aynur Ugur Bilgin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The aim of this study was to evaluate the platelet counts and the mean platelet volume in patients who received isotretinoin for the treatment of acne vulgaris. Method. A total of 110 patients were included in this retrospective study. Complete blood count parameters were recorded prior to and three-months following the treatment. Results. Both platelet counts and the mean platelet volume were significantly decreased following the treatment. No significant differences were noted on the levels of hemoglobin, hematocrit, and white blood cell count. Conclusion. Platelet counts and mean platelet volume significantly decreased following isotretinoin treatment. Since the decrease of platelet counts and the mean platelet volume was seen concomitantly, it is concluded that the effect of isotretinoin was through the suppression of bone marrow.